Reproductive and Developmental Toxicity of Metals

  • Thomas W. Clarkson
  • Gunnar F. Nordberg
  • Polly R. Sager

Table of contents

  1. Front Matter
    Pages i-xviii
  2. An Overview of the Reproductive and Developmental Toxicity of Metals

    1. Front Matter
      Pages 1-1
    2. T. W. Clarkson, G. F. Nordberg, P. R. Sager, M. Berlin, L. Friberg, D. R. Mattison et al.
      Pages 1-25
  3. Review Articles

    1. Front Matter
      Pages 27-27
    2. Maths Berlin, Insu P. Lee, Lonnie D. Russell
      Pages 27-40
    3. Donald R. Mattison, Allen H. Gates, Alain Leonard, Mariann Wide, Karri Hemminki, J. H. J. Copius Peereboom-Stegeman
      Pages 41-91
    4. N. Karle Mottet, Vergil H. Ferm
      Pages 93-125
    5. Richard K. Miller, Zahir A. Shaikh
      Pages 151-204
    6. Harold H. Sandstead, Richard A. Doherty, Kathryn A. Mahaffey
      Pages 205-224
  4. Invited Papers

    1. Front Matter
      Pages 225-225
    2. Effects of Metals on the Male Reproductive System

    3. Effects of Metals on the Female Reproductive System

      1. Mariann Wide
        Pages 343-355
      2. A. Leonard, G. B. Gerber, P. Jacquet
        Pages 357-368
      3. Kari Hemminki, Marja-Liisa Niemi, Pentti Kyyronen, Kari Koskinen, Harri Vainio
        Pages 369-380
    4. Birth Defects and Perinatal Toxicity

      1. Vergil H. Ferm, David P. Hanlon
        Pages 383-397
      2. F. William Sunderman Jr., Marilyn C. Reid, Samuel K. Shen, Catharine B. Kevorkian
        Pages 399-416
    5. The Developing Central Nervous System

    6. Prenatal Aspects of the Metabolism of Metals

    7. Postnatal Aspects of the Metabolism of Metals

  5. Special Topic Papers

  6. Back Matter
    Pages 831-845

About this book


The Permanent Commission and International Association on Occupational Health (PCIAOH) established in 1969 a Subcommittee on the Toxicology of Metals under the chairmanship of Lars Friberg. This committee, which later was named the Scientific Committee on the Toxicology of Metals, has organized a number of previous meetings that have led to publications in three major areas of metal toxicology: a preliminary meeting in Slanchev Bryag, Bulgaria in- 1971, followed by a meeting in 1972 in Buenos Aires, Argentina which produced two reports (Dukes and Friberg, 1971; Task Group on Metal Accumulation, 1973), that discussed the metabolism of metals with special reference to absorption, excretion and biological half-times. The effects and dose-response relationships of toxic metals, including a discussion of general principles, was the second major topic addressed by the Scientific Committee at a meeting in Tokyo in 1974 (Nordberg, 1976). The philosophy of this conference, as well as the previous one in Buenos Aires, was based on the concept of a "threshold dose" for the occurrence of adverse effects. In a conference held in Atlanta, USA in 1980, the scope of discussion on metal effects was broadened to include the role of metals in carcinogenesis. Thus, for the first time, the Scientific Committee took under consideration the possibility of non-threshold relationships (Belman and Nordberg, 1981). In addition, the Scientific Committee on the Toxicology of Metals organized a workshop on metal interactions in Stockholm 1977 (Nordberg et al.


Mamma absorption carcinogenesis development health metabolism metals nervous system philosophy relationships toxicity toxicology

Editors and affiliations

  • Thomas W. Clarkson
    • 1
  • Gunnar F. Nordberg
    • 2
  • Polly R. Sager
    • 1
  1. 1.Division of Toxicology Department of Radiation Biology and BiophysicsUniversity of Rochester School of MedicineRochesterUSA
  2. 2.Department of Environmental MedicineUniversity of UmeaUmeaSweden

Bibliographic information