Cytochromes P-450 and b5

1. Session II

   1. Part 2

      1. On the Structure of Putidaredoxin and Cytochrome P-450cam and their Mode of Interaction

         • Karl Dus

         Pages 287-309

      2. Metabolic Control of Cytochrome P-450cam

         • Julian A. Peterson, Donald M. Mock

         Pages 311-324

      3. General Discussion

         • David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer

         Pages 325-333

2. Session III

   1. Relationship Between Microsomal Hydroxylase and Glucuronyltransferase

      • Herbert Remmer, Karl W. Bock, Bernhard Rexer

      Pages 335-341

   2. A Possible Role of Copper in the Regulation of Heme Biosynthesis Through Ferrochelatase

      • G. S. Wagner, T. R. Tephly

      Pages 343-354

   3. Mixed Function Oxidation and Intermediary Metabolism: Metabolic Interdependencies in the Liver

      • Ronald G. Thurman, Donald P. Marazzo, Roland Scholz

      Pages 355-367

   4. Dissociation of Microsomal Ethanol Oxidation from Cytochrome P-450 Catalyzed Drug Metabolism

      • Kostas P. Vatsis, Martin P. Schulman

      Pages 369-382

   5. General Discussion

      • David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer

      Pages 383-386

3. Session IV

   1. Interaction Between Microsomal Electron Transfer Pathways

      • John B. Schenkman, Ingela Jansson

      Pages 387-404

   2. Role of Cytochrome b5 in the NADH Synergism of NADPH-Dependent Reactions of the Cytochrome P-450 Monooxygenase System of Hepatic Microsomes

      • G. J. Mannering

      Pages 405-434

   3. The Role of Cytochrome b5 in Cytochrome P-450 Enzymes

      • H. A. Sasame, S. S. Thorgeirsson, J. R. Mitchell, J. R. Gillette

      Pages 435-445

   4. Role of Cytochrome b5 in NADPH- and NADH-Dependent Hydroxylation by the Reconstituted Cytochrome P-450- or P-448-Containing System

      • Anthony Y. H. Lu, Wayne Levin, Susan B. West, Mary Vore, Dene Ryan, Ronald Kuntzman et al.

      Pages 447-466

   5. The Role of Cytochrome b5 in Mixed Function Oxidations: Effect of Microsomal Binding of the Hemoprotein on Hepatic N-Demethylations

      • Dominick L. Cinti, Juris Ozols

      Pages 467-483

   6. Comparison of Methods to Study Enzyme Induction in Man

      • Ivar Roots, Klaus Saalfrank, Alfred G. Hildebrandt

      Pages 485-502

   7. General Discussion

      • David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer

      Pages 503-510

4. Back Matter

   Pages 511-554

   PDF

P-450 has in common with our nation that it can call Phila­ delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog­ nized here -- an odd CO-combining pigment without family or func­ tion. Japanese workers identified it as an unusual member of the cytochrome family. Finally, in Philadelphia, its biological func­ tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of the 21-steroid hydroxylase system of adrenocortical microsomes, P-450 has proved to play the same role in a wide variety of other mixed function oxidase systems involved in biosynthesis and catabolism of specific cell or body components as well as in the metabolism of foreign substances entering organisms. P-450-like oxygenating enzymes appear to be fundamental cellular constituents in most forms of aerobic organisms. Activation of molecular oxygen and incorporation of one of its atoms into organic compounds as cata­ lyzed by P-450 enzymes are reactions of vital importance not only for biosynthesis and degradation of steroid hormones necessary for sustaining life, but also for metabolic activation or inactivation of foreign agents such as drugs, food preservatives and additives, insecticides and carcinogens. Moreover, P-450 linked enzyme sys­ tems can either be induced or suppressed by these agents with significant biological consequences.

• Mammalia
• atoms
• biological
• biosynthesis
• cell
• degradation
• enzyme
• enzymes
• food
• growth
• insects
• metabolism
• oxygen
• structure
• system

• Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, USA

  David Y. Cooper, Otto Rosenthal

• Department of Pharmacology, Thomas Jefferson University, Philadelphia, USA

  Robert Snyder, Charlotte Witmer

Policies and ethics