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Cytochromes P-450 and b5

Structure, Function, and Interaction

  • David Y. Cooper
  • Otto Rosenthal
  • Robert Snyder
  • Charlotte Witmer

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 58)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Session I

    1. Part 1

      1. W. Levin, A. Y. H. Lu, D. Ryan, S. West, R. Kuntzman, A. H. Conney
        Pages 1-24
      2. Minor J. Coon, Theodore A. van der Hoeven, David A. Haugen, F. Peter Guengerich, Janice L. Vermilion, David P. Ballou
        Pages 25-46
      3. Karl Dus, William J. Litchfield, Anne G. Miguel, Theodore A. van der Hoeven, David A. Haugen, William L. Dean et al.
        Pages 47-53
      4. David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer
        Pages 73-80
    2. Part 2

      1. Helmut Greim, Peter Czygan, Anthony J. Garro, Ferenc Hutterer, Fenton Schaffner, Hans Popper et al.
        Pages 103-115
      2. Ferenc Hutterer, Kenneth Dressler, Helmut Greim, Peter Czygan, Fenton Schaffner, Hans Popper
        Pages 117-126
      3. David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer
        Pages 165-173
  3. Session II

    1. Part 1

      1. Charlotte Witme, Peter Nehls, Peter Krauss, Herbert Remmer, Robert Snyder
        Pages 175-187
      2. J. O. Stern, E. Peisach, J. Peisach, W. E. Blumberg, A. Y. H. Lu, S. West et al.
        Pages 189-202
      3. David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer
        Pages 229-237
    2. Part 2

      1. Robert Grundin, Peter Moldéus, Helena Vadi, Sten Orrenius, Christer von Bahr, Dan Bäckström et al.
        Pages 251-269
      2. Julian A. Peterson, Donald M. Mock
        Pages 311-324
      3. David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer
        Pages 325-333
  4. Session III

    1. Herbert Remmer, Karl W. Bock, Bernhard Rexer
      Pages 335-341
    2. Ronald G. Thurman, Donald P. Marazzo, Roland Scholz
      Pages 355-367
    3. David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer
      Pages 383-386
  5. Session IV

    1. John B. Schenkman, Ingela Jansson
      Pages 387-404
    2. H. A. Sasame, S. S. Thorgeirsson, J. R. Mitchell, J. R. Gillette
      Pages 435-445
    3. Anthony Y. H. Lu, Wayne Levin, Susan B. West, Mary Vore, Dene Ryan, Ronald Kuntzman et al.
      Pages 447-466
    4. Ivar Roots, Klaus Saalfrank, Alfred G. Hildebrandt
      Pages 485-502
    5. David Y. Cooper, Otto Rosenthal, Robert Snyder, Charlotte Witmer
      Pages 503-510
  6. Back Matter
    Pages 511-554

About this book

Introduction

P-450 has in common with our nation that it can call Phila­ delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog­ nized here -- an odd CO-combining pigment without family or func­ tion. Japanese workers identified it as an unusual member of the cytochrome family. Finally, in Philadelphia, its biological func­ tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of the 21-steroid hydroxylase system of adrenocortical microsomes, P-450 has proved to play the same role in a wide variety of other mixed function oxidase systems involved in biosynthesis and catabolism of specific cell or body components as well as in the metabolism of foreign substances entering organisms. P-450-like oxygenating enzymes appear to be fundamental cellular constituents in most forms of aerobic organisms. Activation of molecular oxygen and incorporation of one of its atoms into organic compounds as cata­ lyzed by P-450 enzymes are reactions of vital importance not only for biosynthesis and degradation of steroid hormones necessary for sustaining life, but also for metabolic activation or inactivation of foreign agents such as drugs, food preservatives and additives, insecticides and carcinogens. Moreover, P-450 linked enzyme sys­ tems can either be induced or suppressed by these agents with significant biological consequences.

Keywords

Mammalia atoms biological biosynthesis cell degradation enzyme enzymes food growth insects metabolism oxygen structure system

Editors and affiliations

  • David Y. Cooper
    • 1
  • Otto Rosenthal
    • 1
  • Robert Snyder
    • 2
  • Charlotte Witmer
    • 2
  1. 1.Harrison Department of Surgical ResearchUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.Department of PharmacologyThomas Jefferson UniversityPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-9026-2
  • Copyright Information Springer-Verlag US 1975
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-9028-6
  • Online ISBN 978-1-4615-9026-2
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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