Morris Hepatomas

Mechanisms of Regulation

  • Harold P. Morris
  • Wayne E. Criss

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 92)

Table of contents

  1. Front Matter
    Pages i-x
  2. Overview of Knowledge by Assessments from the System of Morris “Minimal Deviation” Hepatomas

  3. Nuclear Composition

    1. H. Busch, N. R. Ballal, R. K. Busch, Y. C. Choi, F. Davis, I. L. Goldknopf et al.
      Pages 125-180
    2. Jen-Fu Chiu, Lubomir S. Hnilica, Luc Belanger, H. P. Morris
      Pages 181-203
    3. Woon Ki Paik, Samuel Nochumson, Sangduk Kim
      Pages 205-232
  4. Regulations of Nuclear Functioning

    1. Peter Ove, Mona L. Coetzee
      Pages 233-271
    2. Samson T. Jacob, Kathleen M. Rose, Thomas B. Leonard, Barry W. Duceman
      Pages 273-288
    3. Philip Feigelson, Linda W. DeLap
      Pages 307-330
  5. Intracellular Organelles and Membranes

  6. Regulation of Cytoplasmic Functioning

    1. Wayne E. Criss, Perpetua Muganda, Atul Sahai, Harold P. Morris
      Pages 489-516
    2. E. Randerath, A. S. Gopalakrishnan, K. Randerath
      Pages 517-564
    3. Gerhard Schreiber, Jörg Urban, Heide Dryburgh, T. R. Bradley
      Pages 565-582
  7. Vitamins, Minerals, and Diet

  8. Experimental Therapy

  9. Back Matter
    Pages 759-775

About this book


In 1960, Dr. Van R. Potter and Dr. Henry Pitot (at McCardle Laboratory in Madison, Wisconsin), Dr. Tetsuo Ono (then at McCardle Laboratory and now at the Japanese Foundation for Cancer Research in Tokyo, Japan) and Dr. Harold P. Morris (then at the National Cancer Institute and now at Howard University, Washington, D. C. ) decided that an experimental cancer model would be an invaluable tool to examine neoplastic changes in cells. Since they were study­ ing the various highly specific metabolic processes which are unique to liver tissues, they determined that a transplantable liver cancer model would be the ideal system to work with. This system would provide for comparison of normal liver tissue of the non-tumor bear­ ing animal, the tumor bearing animal's (host) liver and the liver cancer. Dr. Morris undertook a series of rat studies employing several chemicals known to cause liver cancer. Soon the first Morris hepatomas (#3683, 3924A, 5123) were being studied by several labs. During the next 18 years, Dr. Morris developed and transplanted numerous strains of hepatomas of which no two were identical. These tumors ranged from the very slowly-growing, highly differentiated cancer tissues, e. g. , 96l8A which is a diploid tumor containing gly­ cogen and a "nearly normal" complement of enzymes, to a large group of rapidly-growing, poorly differentiated cancer tissues, e. g.


Laboratory cancer cancer research cells enzymes liver research tissue tumor

Editors and affiliations

  • Harold P. Morris
    • 1
  • Wayne E. Criss
    • 1
  1. 1.Department of Biochemistry and Howard Cancer Research CenterHoward University Medical SchoolUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1978
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4615-8854-2
  • Online ISBN 978-1-4615-8852-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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