Research Methods in Neurochemistry

Volume 1

  • Neville Marks
  • Richard Rodnight

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Ultrastructure and Fragmentation of Neural Tissues

    1. Front Matter
      Pages 1-1
    2. Betty I. Roots, Patricia V. Johnston
      Pages 3-17
    3. Shirley E. Poduslo, William T. Norton
      Pages 19-32
    4. Martha Spohn, Alan N. Davison
      Pages 33-43
    5. Claire E. Zomzely-Neurath, Sidney Roberts
      Pages 95-137
    6. Bruce S. McEwen, Richard E. Zigmond
      Pages 139-161
  3. Properties of Intact Neural Tissues

  4. Components of Neural Tissues

    1. Front Matter
      Pages 221-221
    2. Lloyd A. Horrocks, Grace Y. Sun
      Pages 223-231
    3. Richard U. Margolis, Renée K. Margolis
      Pages 249-284
  5. Biologically Active Amines

    1. Front Matter
      Pages 285-285
    2. Solomon H. Snyder, Kenneth M. Taylor
      Pages 287-315
  6. Back Matter
    Pages 357-368

About this book


On picking up this first volume of a new series of books the reader may ask the two questions: (a) why research methods? and (b) why in neurochem­ istry? The answers to these questions are easy - they more than justify the volumes to come and show the strong need for their existence. It is customary to think of methods as a necessary but unexciting means to an end - to relegate advances in methodology to a minor role in the creative, original portion of advances in science. This is not the case; the pace-setting function of methodology is well illustrated in most areas of neurobiology. To formulate our questions to Nature (which is the essence of experimental design), methodology is needed; to get answers to our ques­ tions we have to devise yet new methods. The chapters of the present volume fully illustrate how the development of a new method can cut a new path­ how it can open new fields, just as the microscope founded histology. Heter­ ogeneity of structures presents a formidable challenge for methodology in the nervous system, yet methods for separating the structures are essential if we ever want to decipher the enigma of functional contribution of the ele­ ments to the whole. The problem is not only physical separation-clearly methods are essential to study complex structures in situ.


nervous system neurobiology neurochemistry

Editors and affiliations

  • Neville Marks
    • 1
  • Richard Rodnight
    • 2
  1. 1.New York State Research InstituteNeurochemistry and Drug AddictionNew YorkUSA
  2. 2.Department of Biochemistry, Institute PsychiatryUniversity of LondonLondonGreat Britain

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