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Metabolic Turnover in the Nervous System

  • Sidney Roberts
  • P. Greengard
  • J. M. Ritchie
  • Michael M. Brand
  • G. M. Lehrer
  • Margaret R. Murray
  • N. Marks
  • A. Lajtha
  • R. Rodnight
  • Paul Mandel
  • Monique Jacob
  • Robert Main Burton
  • Yasuzo Tsukada
  • Hrachia Chachatur Buniatian
  • Sze-Chuh Cheng

Table of contents

  1. Front Matter
    Pages i-xxi
  2. Sidney Roberts
    Pages 1-48
  3. N. Marks, A. Lajtha
    Pages 49-139
  4. R. Rodnight
    Pages 141-163
  5. Paul Mandel, Monique Jacob
    Pages 165-198
  6. Robert Main Burton
    Pages 199-214
  7. Yasuzo Tsukada
    Pages 215-233
  8. Hrachia Chachatur Buniatian
    Pages 235-247
  9. Paul Mandel
    Pages 249-281
  10. Sze-Chuh Cheng
    Pages 283-315
  11. P. Greengard, J. M. Ritchie
    Pages 317-335
  12. Michael M. Brand, G. M. Lehrer
    Pages 337-371
  13. Margaret R. Murray
    Pages 373-438
  14. Back Matter
    Pages xxiii-xxxix

About this book

Introduction

Volume V deals with the problems of turnover in the nervous system. "Turnover" is defined in different ways, and the term is used in different contexts. It is used rather broadly in the present volume, and intentionally so. The turnover of macromolecules is only one aspect; here "turnover" in­ dicates the simultaneous and coordinated formation and breakdown of macromolecular species. The complexities of cerebral protein turnover are shown in a separate chapter dealing with the synthesis of proteins, in another on breakdown, and in still another on the relationship of these two (showing how the two halves of turnover are controlled). The fact that most likely the two halves of protein turnover, synthesis and breakdown, are separated spatially and the mechanisms involved are different further emphasizes the complexity of macromolecular turnover. "Turnover" is used in a different context when the turnover of a cycle is discussed; but here again a number of complex metabolic reactions have to be interrelated and controlled; some such cycles are discussed briefly in this volume, additional cycles have been discussed with metabolism, and some cycles still await elucidation or discovery.

Keywords

biochemistry complexity nervous system proteins system

Authors and affiliations

  • Sidney Roberts
    • 1
  • P. Greengard
    • 2
  • J. M. Ritchie
    • 2
  • Michael M. Brand
    • 3
  • G. M. Lehrer
    • 3
  • Margaret R. Murray
    • 4
  • N. Marks
    • 5
  • A. Lajtha
    • 5
  • R. Rodnight
    • 6
  • Paul Mandel
    • 7
  • Monique Jacob
    • 7
  • Robert Main Burton
    • 8
  • Yasuzo Tsukada
    • 9
  • Hrachia Chachatur Buniatian
    • 10
  • Sze-Chuh Cheng
    • 5
  1. 1.Department of Biological Chemistry School of Medicine and the Brain Research InstituteUniversity of California Center for the Health SciencesLos AngelesUSA
  2. 2.Department of PharmacologyYale University School of MedicineNew HavenUSA
  3. 3.The Division of Neurochemistry Department of NeurologyThe Mount Sinai School of MedicineNew YorkUSA
  4. 4.Departments of Anatomy and Surgery College of Physicians and SurgeonsColumbia UniversityNew YorkUSA
  5. 5.New York State Research Institute for Neurochemistry and Drug AddictionUSA
  6. 6.Department of Biochemistry Institute of PsychiatryBritish Postgraduate Medical Federation University of LondonLondonEngland
  7. 7.Centre de Neurochimie duCentre National de la Recherche ScientifiqueStrasbourgFrance
  8. 8.Department of Pharmacology and the Beaumont-May Institute of NeurologyWashington University School of MedicineSt. LouisUSA
  9. 9.Department of Physiology School of MedicineKeio UniversityTokyoJapan
  10. 10.Institute of BiochemistryAcademy of Sciences of Armenian S.S.R.YerevanArmenia S.S.R.

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