Clinical Approach to Infection in the Compromised Host

  • Robert H. Rubin
  • Lowell S. Young

Table of contents

  1. Front Matter
    Pages i-xxix
  2. Lowell S. Young, Robert H. Rubin
    Pages 1-4
  3. James C. Wade, Stephen C. Schimpff
    Pages 5-40
  4. Jos W. M. Van Der Meer
    Pages 41-73
  5. Lowell S. Young
    Pages 75-114
  6. John S. Wolfson, Arthur J. Sober
    Pages 115-130
  7. Donald Armstrong, Bruce Polsky
    Pages 165-191
  8. Françoise Meunier
    Pages 193-220
  9. Joel Ruskin
    Pages 253-304
  10. Neil M. Ampel, Edward J. Wing
    Pages 305-324
  11. Jules L. Dienstag
    Pages 325-345
  12. Michael S. Gottlieb
    Pages 381-405
  13. Joel D. Meyers, E. Donnall Thomas
    Pages 525-556
  14. Layne O. Gentry, Barry Zeluff
    Pages 623-648
  15. Back Matter
    Pages 669-685

About this book


"Infection in the Compromised Host" has become a classic chapter in textbooks devoted to infectious diseases and internal medicine. The numbers of compromised hosts are increasing in the era of modem medicine because of our expanded capabilities to deal with difficult diseases, especially neoplasms. As a consequence, microbiologic complications related to the intensive care administered to these patients are increasing as well. Under these circum­ stances, not only does the underlying illness create conditions favorable for the development of unusual infections, but often the therapy contributes to the acquisition of potential pathogens that tum into agents responsible for severe and frequently fatal disease. Granulocytopenia and immunosuppression have been the two key factors in predisposing patients with cancer and other serious diseases to severe bacterial infections. Colonization by hospital-acquired pathogens and breaks in the anatomic barriers-as a result of disease or medical intervention-have contributed to the high incidence of infectious diseases in these patients. Although there is some overlap between the types of infection in granulocytopenic and immunosuppressed hosts, each of these clinical entities has distinctive features thatjustify considering them separately, reserving the term immunocompromised hosts only when refer­ ring to patients who are predisposed to opportunistic infections. For about two decades, infections in granulocytopenic patients have attracted the atten­ tion of clinicians because they represent a model for the study of antimicrobial drugs in hosts deprived of an essential element of defense against bacterial infection, that is, an adequate number of normally functioning granulocytes.


AIDS HIV anemia antibiotic histopathology immunology infection infectious diseases intensive care internal medicine leukemia oncology prevention sepsis steroids

Editors and affiliations

  • Robert H. Rubin
    • 1
  • Lowell S. Young
    • 2
  1. 1.Infectious Disease and Transplantation Units, Massachusetts General Hospital and Department of MedicineHarvard Medical SchoolBostonUSA
  2. 2.Division of Infectious Diseases, Pacific Presbyterian Medical CenterKuzell Institute for Arthritis and Infectious DiseasesSan FranciscoUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology