© 1997

Oxidative Stress and Signal Transduction

  • Henry Jay Forman
  • Enrique Cadenas

Table of contents

  1. Front Matter
    Pages i-xv
  2. Immediate Cellular Responses to Oxidative Stress and the Production of Second Messengers

    1. Front Matter
      Pages 1-1
    2. Nathan Spear, Alvaro G. Estévez, Rafael Radi, Joseph S. Beckman
      Pages 32-51
    3. Christoph Richter, Renato Laffranchi
      Pages 52-76
    4. Alex Sevanian, Julia Rashba-Step
      Pages 77-107
    5. Viswanathan Natarajan, William M. Scribner, Suryanarayana Vepa
      Pages 108-133
    6. Richard J. Kulmacz, William E. M. Lands
      Pages 134-156
    7. Rayudu Gopalakrishna, Zhen-Hai Chen, Usha Gundimeda
      Pages 157-180
    8. Gary L. Schieven
      Pages 181-199
  3. The Connection of Oxidative Induced Changes in Second Messengers and Transcription Factors with Activation of Gene Expression

    1. Front Matter
      Pages 237-237
    2. Klaus Schulze-Osthoff, Manuel Bauer, Markus Vogt, Sebastian Wesselborg, Patrick A. Baeuerle
      Pages 239-259
    3. Amy R. Simon, Barry L. Fanburg, Brent H. Cochran
      Pages 260-271
    4. Leonard V. Favreau, Cecil B. Pickett
      Pages 272-288
    5. Roy H. Burdon
      Pages 289-319
  4. Gene Expression in Response to Oxidative Stress

    1. Front Matter
      Pages 321-321
    2. Angelo Azzi, Daniel Boscoboinik, Orazio Cantoni, Agata Fazzio, Dominique Marilley, Valerie O’Donnell et al.
      Pages 323-342
    3. Yvonne M. W. Janssen, Cynthia R. Timblin, Christine L. Zanella, L. Albert Jimenez, Brooke T. Mossman
      Pages 387-414

About this book


In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.


Activation Calcium gene expression regulation transcription

Editors and affiliations

  • Henry Jay Forman
    • 1
  • Enrique Cadenas
    • 1
  1. 1.University of Southern CaliforniaUSA

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