Bioenergetics of the Cell: Quantitative Aspects

  • Valdur A. Saks
  • Renée Ventura-Clapier
  • Xavier Leverve
  • André Rossi
  • Michel Rigoulet

Part of the Developments in Molecular and Cellular Biochemistry book series (DMCB, volume 25)

Table of contents

  1. Front Matter
    Pages i-1
  2. What do we not know of cellular bioenergetics? — a general view on the state of the art

    1. Front Matter
      Pages 3-3
    2. Valdur A. Saks, Renée Ventura-Clapier, Xavier Leverve, André Rossi, Michel Rigoulet
      Pages 3-9
  3. Bioenergetics of Mitochondria: in Vitro and in vivo Studies

    1. Front Matter
      Pages 11-11
    2. O. V. Demin, B. N. Kholodenko, V. P. Skulachev
      Pages 21-33
    3. Michel Rigoulet, Xavier Leverve, Eric Fontaine, Rachid Ouhabi, Bernard Guérin
      Pages 35-52
    4. Xavier Leverve, Brigitte Sibille, Anne Devin, Marie-Astrid Piquet, Pascal Espié, Michel Rigoulet
      Pages 53-65
    5. Nicole Avéret, Valérie Fitton, Odile Bunoust, Michel Rigoulet, Bernard Guérin
      Pages 67-79
    6. Valdur A. Saks, Vladimir I. Veksler, Andrei V. Kuznetsov, Laurence Kay, Peeter Sikk, Toomas Tiivel et al.
      Pages 81-100
    7. L. Rappaport, P. Oliviero, J. L. Samuel
      Pages 101-105
    8. Anne Devin, Pascal Espié, Bernard Guérin, Michel Rigoulet
      Pages 107-121
  4. Energy Transfer Networks: Molecular Physiology of Kinases, Lessons from Transgenic Mice, Mathematical Theories

    1. Front Matter
      Pages 123-123
    2. Uwe Schlattner, Michael Forstner, Michael Eder, Olaf Stachowiak, Karin Fritz-Wolf, Theo Wallimann
      Pages 125-140
    3. Wenning Qin, Zaza Khuchua, Judy Cheng, Jaime Boero, R. Mark Payne, Arnold W. Strauss
      Pages 153-167
    4. Petras P. Dzeja, Robert J. Zeleznikar, Nelson D. Goldberg
      Pages 169-182
    5. Karen Steeghs, Frank Oerlemans, Arnold de Haan, Arend Heerschap, Lia Verdoodt, Martine de Bie et al.
      Pages 183-194
    6. Klaas Nicolay, Ferdi A. van Dorsten, Torsten Reese, Marijn J. Kruiskamp, Johannes F. Gellerich, Cees J. A. van Echteld
      Pages 195-208
    7. Mayis K. Aliev, F. A. van Dorsten, M. G. Nederhoff, C. J. A. van Echteld, Vladimir Veksler, Klaas Nicolay et al.
      Pages 209-229
    8. R. Ventura-Clapier, A. Kuznetsov, V. Veksler, E. Boehm, K. Anflous
      Pages 231-247
    9. Graham J. Kemp, David N. Manners, Joseph F. Clark, Mark E. Bastin, George K. Radda
      Pages 249-289
    10. Valdur Saks, Pierre Dos Santos, Frank N. Gellerich, Philippe Diolez
      Pages 291-307
  5. Metabolic Signalling and Calcium: Regulation of Mitochondrial Oxidative Phosphorylation in vivo

    1. Front Matter
      Pages 309-309
    2. Boris N. Kholodenko, Johann M. Rohwer, Marta Cascante, Hans V. Westerhoff
      Pages 311-320
    3. J. H. G. M. van Beek, X. Tian, C. J. Zuurbier, B. de Groot, C. J. A. van Echteld, M. H. J. Eijgelshoven et al.
      Pages 321-344
    4. Laurence S. Jouaville, François Ichas, Jean-Pierre Mazat
      Pages 371-376
  6. Bioenergetics and Medicine

  7. Back Matter
    Pages 457-460

About this book


This volume continues the discussion of the problems of in vivo and in vitro. The recently solved X-ray structure of the mitochondrial creatine kinase and its molecular biology cellular bioenergetics - the tradition we started in 1994 by publication of the focused issue of Molecular and Cellular are analyzed with respect to its molecular physiology and Biochemistry, volume 133/134 and a book 'Cellular Bio­ functional coupling to the adenine nucleotide translocase, as energetics: role of coupled creatine kinases' edited by V. Saks well as its participation, together with the adenylate kinase and R. Ventura-Clapier and published by Kluwer Publishers, system, in intracellular energy transfer. The results of the Dordrecht -Boston. In the present volume, use of quantitative studies of creatine kinase deficient transgenic mice are methods of studies of organized metabolic systems, such as summarized and analyzed by using mathematical models of mathematical modeling and Metabolic Control Analysis, for the compartmentalized energy transfer, thus combining two investigation of the problems of bioenergetics of the cell is powerful new methods of the research. All these results, described together with presentation of new experimental together with the physiological and NMR data on the cardiac results. The following central problems of the cellular bio­ metabolic and mitochondrial responses to work-load changes energetics are the focus of the discussions: the mechanisms concord to the concept of metabolic networks of energy of regulation of oxidative phosphorylation in the cells in vivo transfer and feedback regulation.


Calcium Nucleotide biology enzyme enzymes metabolism mitochondria molecular biology phosphorylation

Editors and affiliations

  • Valdur A. Saks
    • 1
    • 3
  • Renée Ventura-Clapier
    • 2
  • Xavier Leverve
    • 3
  • André Rossi
    • 3
  • Michel Rigoulet
    • 4
  1. 1.Laboratories of BioenergeticsInstitute of Chemical and Biological PhysicsTallinnEstonia
  2. 2.Cellular and Molecular CardiologyChatenay-MalabryFrance
  3. 3.Laboratory of BioenergeticsJoseph Fourier UniversityGrenobleFrance
  4. 4.Laboratory of BioenergeticsInstitute of Biochemistry and Cellular Genetics CNRSBordeauxFrance

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