© 1999

Triple Helix Forming Oligonucleotides

  • Claude Malvy
  • Annick Harel-Bellan
  • Linda L. Pritchard

Part of the Perspectives in Antisense Science book series (DARE, volume 2)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Background and Structural Aspects

  3. The Biology of Triple Helices

    1. Front Matter
      Pages 99-99
    2. L. James Maher
      Pages 101-115
    3. Scot W. Ebbinghaus, Nadarajah Vigneswaran, Charles M. Mayfield, David T. Curiel, Donald M. Miller
      Pages 117-127
    4. Fedor Svinarchuk, Claude Malvy
      Pages 145-157
    5. Marina Kochetkova, Mary Frances Shannon
      Pages 159-166
    6. Karen M. Vasquez, Peter M. Glazer
      Pages 167-179
    7. François-Xavier Barre, Linda L. Pritchard, Annick Harel-Bellan
      Pages 181-192
    8. Sergei M. Mirkin
      Pages 193-222
    9. Anne-Laure Guieysse, Daniele Praseuth
      Pages 223-231
    10. Kyonggeun Yoon, Jörg Jendis, Karin Moelling
      Pages 233-242

About this book


Sequence-specific DNA binding ligands, amongst which triple helix forming oligonucleotides are the most efficient as yet, represent promising tools in a number of fields. One of their most promising applications is as antiviral tools: they can specifically target a viral gene, even if it is integrated into the host genome, and be used to specifically inactivate the viral gene or even destroy the cells harboring this gene. However, from science fiction to science there remains a gap; and we are at the moment on the threshold of this fascinating field. Triple Helix Forming Oligonucleotides considers the different aspects of the design and improvement, current or future, of these molecules and their structural analysis, as well as their applications, with special emphasis on the attempts to obtain biological effects of these potentially important tools. What emerges is that the current state of the research is encouraging, and that these molecules are already useful in some biotechnology applications.


DNA Nucleotide Purine RNA Vivo genes microscopy transcription

Editors and affiliations

  • Claude Malvy
    • 1
  • Annick Harel-Bellan
    • 1
  • Linda L. Pritchard
    • 1
  1. 1.CNRSFrance

Bibliographic information

  • Book Title Triple Helix Forming Oligonucleotides
  • Editors Claude Malvy
    Annick Harel-Bellan
    Linda L. Pritchard
  • Series Title Perspectives in Antisense Science
  • DOI
  • Copyright Information Kluwer Academic Publishers 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-7923-8418-2
  • Softcover ISBN 978-1-4613-7358-2
  • eBook ISBN 978-1-4615-5177-5
  • Series ISSN 1566-0389
  • Edition Number 1
  • Number of Pages XV, 297
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Cell Biology
    Biochemistry, general
    Human Genetics
  • Buy this book on publisher's site
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