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© 1998

Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning

  • Margaret M. McCarthy
Book

Part of the Perspectives in Antisense Science book series (DARE, volume 1)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Rainer Spanagel, Bernd Schöbitz, Mario Engelmann
    Pages 27-41
  3. Genoveva Davidkova, Sui-Po Zhang, Long-Wu Zhou, Benjamin Weiss
    Pages 61-82
  4. Back Matter
    Pages 171-172

About this book

Introduction

When first introduced, antisense oligonucleotides were hailed as the long awaited magic bullet that would provide an unprecedented level of specificity in controlling gene expression. Following this initial enthusiasm, antisense oligonucleotides have been maligned as nonspecific, toxic, and essentially useless. However, application of antisense oligonucleotide technology in the nervous system stands apart from the use of this technique in peripheral systems, largely because of its enormous success. The source of this success remains a matter of some controversy.
Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning addresses the origins of that controversy and determines whether the nervous system is a privileged site for antisense oligonucleotide action and not subject to the same vagaries and pitfalls as non-neuronal systems.
Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning contains chapters by experts in the field that focus on the use of this technique in a variety of behavioral systems, as well as rapid and nonspecific effects and the uptake and metabolism of antisense oligonucleotides by the nervous system.
Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning features:
  • experts in the field reporting on the use of antisense oligonucleotide technology in a variety of behavioral systems, including pain control, circadian rhythms, ingestion and control of water balance, and reproductive behaviors;
  • the novel use of plasmids to express antisense RNA in the nervous system;
  • the biodistribution and metabolism of antisense oligonucleotides in the nervous system;
  • rapid and unusual effects; and
  • non-specific effects.

Keywords

Nervous System Nucleotide RNA gene expression metabolism

Editors and affiliations

  • Margaret M. McCarthy
    • 1
  1. 1.University of MarylandBaltimoreUSA

Bibliographic information

  • Book Title Modulating Gene Expression by Antisense Oligonucleotides to Understand Neural Functioning
  • Editors Margaret M. McCarthy
  • Series Title Perspectives in Antisense Science
  • DOI https://doi.org/10.1007/978-1-4615-4933-8
  • Copyright Information Kluwer Academic Publishers 1998
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-7923-8242-3
  • Softcover ISBN 978-1-4613-7238-7
  • eBook ISBN 978-1-4615-4933-8
  • Series ISSN 1566-0389
  • Edition Number 1
  • Number of Pages XI, 172
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
    Neurology
    Biochemistry, general
  • Buy this book on publisher's site
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