© 1998

Resolving the Antibiotic Paradox

Progress in Understanding Drug Resistance and Development of New Antibiotics

  • Barry P. Rosen
  • Shahriar Mobashery

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 456)

Table of contents

  1. Front Matter
    Pages i-x
  2. Didier Mazel, Julian Davies
    Pages 1-6
  3. Stephen A. Lerner
    Pages 7-15
  4. Stuart B. Levy, Mark Nelson
    Pages 17-25
  5. Gerard D. Wright, Albert M. Berghuis, Shahriar Mobashery
    Pages 27-69
  6. Karen Bush, Shahriar Mobashery
    Pages 71-98
  7. Marc Ouellette, Éric Leblanc, Christoph Kündig, Barbara Papadopoulou
    Pages 99-113
  8. Luiz A. Basso, John S. Blanchard
    Pages 115-144
  9. Hendrik W. van Veen, Wil N. Konings
    Pages 145-158
  10. Rita Mukhopadhyay, Jiaxin Li, Hiranmoy Bhattacharjee, Barry P. Rosen
    Pages 159-181
  11. David J. C. Knowles, Frank King
    Pages 183-195
  12. Kenny K. Wong, David L. Pompliano
    Pages 197-217
  13. Michael R. Barbachyn, Steven J. Brickner, Robert C. Gadwood, Stuart A. Garmon, Kevin C. Grega, Douglas K. Hutchinson et al.
    Pages 219-238
  14. Paul M. Hershberger, Thomas P. Demuth Jr.
    Pages 239-267
  15. John M. Domagala, Diane Alessi, Maxwell Cummings, Stephen Gracheck, Liren Huang, Michael Huband et al.
    Pages 269-286
  16. Back Matter
    Pages 287-293

About this book


Antibiotic resistance, once a term appreciated only by microbiologists, has become a common topic in the popular press. Stuart Levy, one of the contributors to this collection, bears some of the responsibility for increasing public awareness with the publication of his book "The Antibiotic Paradox" in 1992: Misuse of antibiotics resulting in increased bacterial resistance had previously been recognized in the infectious disease community. However, Dr. Levy's eloquent public warning about the shrinking efficacy of our antibi­ otic armamentarium served to alert the lay person to the potential consequences of this de­ mise in useful therapy. Because of the proliferation of diverse antibiotic classes with increasing potency and broader activity spectra, it had been assumed that any ordinary bacterial infection could be eradicated with the proper selection of drug. However, it has become evident that we are surrounded by resistant bacteria, many of which were introduced unwittingly into our en­ vironment through the unnecessary use of antibiotics. When it became evident that a number of people were returning for multiple visits to their family physicians for persist­ ent ear infections or non-responsive bronchitis, questions were raised about the antibiotic treatments that were being prescribed. Bacteria resistant to common antibiotic regimens were being isolated more frequently, often as organisms classified as "multi-resistant" with decreased susceptibilities to two or more structural classes of agents. Nosocomial spread of these resistances was aided by the transmission of plasmid-mediated resistance factors between species.


antibiotics bacteria infectious infectious disease infectious diseases

Editors and affiliations

  • Barry P. Rosen
    • 1
  • Shahriar Mobashery
    • 1
  1. 1.Wayne State UniversityDetroitUSA

Bibliographic information

  • Book Title Resolving the Antibiotic Paradox
  • Book Subtitle Progress in Understanding Drug Resistance and Development of New Antibiotics
  • Editors Barry P. Rosen
    Shahriar Mobashery
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 1998
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-46039-5
  • Softcover ISBN 978-1-4613-7220-2
  • eBook ISBN 978-1-4615-4897-3
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages X, 293
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacy
    Medical Microbiology
    Medical Biochemistry
    Infectious Diseases
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals