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Molecular and Cellular Mechanisms of Neuronal Plasticity

Basic and Clinical Implications

  • Yigal H. Ehrlich

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 446)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Daniel Tomsic, Arturo Romano, Héctor Maldonado
    Pages 17-35
  3. Yigal H. Ehrlich, Michael V. Hogan, Zofia Pawlowska, Andrzej Wieraszko, Ethel Katz, Tomasz Sobocki et al.
    Pages 51-71
  4. Albert Y. Sun, Yong-Mei Chen
    Pages 73-83
  5. L. H. J. Aarts, P. Schotman, J. Verhaagen, L. H. Schrama, W. H. Gispen
    Pages 85-106
  6. Philip C. Wong, David R. Borchelt, Michael K. Lee, Carlos A. Pardo, Gopal Thinakaran, Lee J. Martin et al.
    Pages 145-159
  7. Kira S. Ermekova, Alex Chang, Nicola Zambrano, Paola de Candia, Tommaso Russo, Marius Sudol
    Pages 161-180
  8. Efthimia T. Kokotos Leonardi, Catherine Mytilineou
    Pages 203-222
  9. Henryk M. Wisniewski, Wayne Silverman
    Pages 223-225
  10. Back Matter
    Pages 227-229

About this book

Introduction

Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.

Keywords

Alzheimer Nervous System Parkinson gene expression genes neurons

Editors and affiliations

  • Yigal H. Ehrlich
    • 1
    • 2
    • 3
  1. 1.The College of Staten Island of The City University of New YorkUSA
  2. 2.The CSI/IBR Center for Developmental Neuroscience Staten IslandNew YorkUSA
  3. 3.The City University Graduate SchoolNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-4869-0
  • Copyright Information Kluwer Academic/Plenum Publishers 1998
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7209-7
  • Online ISBN 978-1-4615-4869-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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