© 1999

Drug Resistance in Leukemia and Lymphoma III

  • G. J. L. Kaspers
  • R. Pieters
  • A. J. P. Veerman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 457)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Drug Resistance Related Proteins and Glutathione

    1. Jean-Pierre Marie, Ollivier Legrand
      Pages 1-9
    2. Z. Karakaş, L. Ağaoğlu, S. Erdem, G. Yanikkaya Demirel, M. Arasa, F. Süzergöz et al.
      Pages 21-28
    3. Alena W. Elgie, Jean M. Sargent, Christine J. Williamson, Grazyna M. Lewandowicz, Colin G. Taylor
      Pages 29-33
    4. E. Wattel, E. Solary, B. Hecquet, D. Caillot, N. Ifrah, A. Brion et al.
      Pages 35-46
    5. R. Advani, G. Visani, D. Milligan, H. Saba, M. Tallman, J. M. Rowe et al.
      Pages 47-56
    6. Annemarie Larkin, Elizabeth Moran, Denis Alexander, Martin Clynes
      Pages 65-70
    7. M. Pallis, J. Turzanski, S. Langabeer, N. H. Russell
      Pages 77-88
    8. M. Monici, F. Fusi, P. Mazzinghi, A. Degli Innocenti o Nocentini, I. Landini, I. Banchelli et al.
      Pages 89-94
    9. C. Tmej, P. Chiba, K.-J. Schaper, G. Ecker, W. Fleischhacker
      Pages 95-105
    10. Barbara De Moerloose, Catharina Dhooge, Jan Philippé
      Pages 107-118
    11. Christian W. van Haselen, Marcel J. Flens, Rik J. Scheper, Paul van der Valk, George L. Scheffer, Johan Toonstra et al.
      Pages 119-131
    12. Robert Pirker, Gudrun Pohl, Thomas Stranzl, Ralf W. Suchomel, Rik J. Scheper, Ulrich Jäger et al.
      Pages 133-139
    13. Martin Filipits, Thomas Stranzl, Gudrun Pohl, Ralf W. Suchomel, Sabine Zöchbauer, Raoul Brunner et al.
      Pages 141-150
    14. Ollivier Legrand, Ghislaine Simonin, Jean-Yves Perrot, Robert Zittoun, Jean-Pierre Marie
      Pages 161-175
    15. T. Köhler, S. Leiblein, S. Borchert, J. Eller, A.-K. Rost, D. Laßner et al.
      Pages 177-185

About this book


Cellular drug resistance is a major limitation to the success of chemotherapy of leu­ kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am­ sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p­ glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in­ formation is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.


Antigen apoptosis chemotherapy drug drug resistance imaging interferon leukemia lymphoma pathogenesis pharmacokinetics pharmacology proteins resistance tumor

Editors and affiliations

  • G. J. L. Kaspers
    • 1
  • R. Pieters
    • 1
  • A. J. P. Veerman
    • 1
  1. 1.University Hospital Vrije UniversiteitAmsterdamThe Netherlands

Bibliographic information

  • Book Title Drug Resistance in Leukemia and Lymphoma III
  • Editors G.J.L. Kaspers
    R. Pieters
    A.J.P. Veerman
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Springer Science+Business Media New York 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-46055-5
  • Softcover ISBN 978-1-4613-7180-9
  • eBook ISBN 978-1-4615-4811-9
  • Series ISSN 0065-2598
  • Series E-ISSN 2214-8019
  • Edition Number 1
  • Number of Pages XIV, 638
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Oncology
    Internal Medicine
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology