Drug Resistance in Leukemia and Lymphoma III

  • G. J. L. Kaspers
  • R. Pieters
  • A. J. P. Veerman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 457)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Drug Resistance Related Proteins and Glutathione

    1. Jean-Pierre Marie, Ollivier Legrand
      Pages 1-9
    2. Z. Karakaş, L. Ağaoğlu, S. Erdem, G. Yanikkaya Demirel, M. Arasa, F. Süzergöz et al.
      Pages 21-28
    3. Alena W. Elgie, Jean M. Sargent, Christine J. Williamson, Grazyna M. Lewandowicz, Colin G. Taylor
      Pages 29-33
    4. E. Wattel, E. Solary, B. Hecquet, D. Caillot, N. Ifrah, A. Brion et al.
      Pages 35-46
    5. R. Advani, G. Visani, D. Milligan, H. Saba, M. Tallman, J. M. Rowe et al.
      Pages 47-56
    6. Annemarie Larkin, Elizabeth Moran, Denis Alexander, Martin Clynes
      Pages 65-70
    7. M. Pallis, J. Turzanski, S. Langabeer, N. H. Russell
      Pages 77-88
    8. M. Monici, F. Fusi, P. Mazzinghi, A. Degli Innocenti o Nocentini, I. Landini, I. Banchelli et al.
      Pages 89-94
    9. C. Tmej, P. Chiba, K.-J. Schaper, G. Ecker, W. Fleischhacker
      Pages 95-105
    10. Barbara De Moerloose, Catharina Dhooge, Jan Philippé
      Pages 107-118
    11. Christian W. van Haselen, Marcel J. Flens, Rik J. Scheper, Paul van der Valk, George L. Scheffer, Johan Toonstra et al.
      Pages 119-131
    12. Robert Pirker, Gudrun Pohl, Thomas Stranzl, Ralf W. Suchomel, Rik J. Scheper, Ulrich Jäger et al.
      Pages 133-139
    13. Martin Filipits, Thomas Stranzl, Gudrun Pohl, Ralf W. Suchomel, Sabine Zöchbauer, Raoul Brunner et al.
      Pages 141-150
    14. Ollivier Legrand, Ghislaine Simonin, Jean-Yves Perrot, Robert Zittoun, Jean-Pierre Marie
      Pages 161-175
    15. T. Köhler, S. Leiblein, S. Borchert, J. Eller, A.-K. Rost, D. Laßner et al.
      Pages 177-185
    16. Dorina M. van der Kolk, Edo Vellenga, Michael Müller, Elisabeth G. E. de Vries
      Pages 187-198
    17. J. M. Sargent, C. Williamson, A. G. Hall, A. W. Elgie, C. G. Taylor
      Pages 205-209
    18. P. Kearns, R. Pieters, M. M. A. Rottier, A. J. P. Veerman, K. Schmiegalow, A. D. J. Pearson et al.
      Pages 211-216
  3. Apoptosis and Cell Death Regulations

    1. Marina Konopleva, Shourong Zhao, Zhong Xie, Harry Segall, Anas Younes, David F. Claxton et al.
      Pages 217-236
    2. Klaus-Michael Debatin
      Pages 237-244
    3. Astrid A. A. M. Danen-Van Oorschot, Alex J. van der Eb, Mathieu H. M. Noteborn
      Pages 245-249
    4. A. Yu. Baryshnikov, E. R. Polosukhina, N. N. Tupitsin, N. V. Gavrikova, L. Yu. Andreeva, T. N. Zabotina et al.
      Pages 251-258
    5. Deborah S. Richardson, Paul D. Allen, Stephen M. Kelsey, Adrian C. Newland
      Pages 259-266
    6. Deborah S. Richardson, Paul D. Allen, Stephen M. Kelsey, Adrian C. Newland
      Pages 267-279
    7. Allen F. Pyesmany, Lynne M. Ball, Margaret Yhap, M. Henry, Krista Laybolt, D. Christie Riddell et al.
      Pages 281-287
    8. Lynne M. Ball, Christopher L. Lannon, Margaret Yhap, Allen F. Pyesmany, M. Henry, Krista Laybolt et al.
      Pages 289-296
    9. Lynne M. Ball, Allen F. Pyesmany, Margaret Yhap, Christopher L. Lannon, M. Henry, Krista Laybolt et al.
      Pages 297-303
    10. Allen F. Pyesmany, Lynne M. Ball, Margaret Yhap, M. Henry, Krista Laybolt, D. Christie Riddell et al.
      Pages 305-312
    11. Barbara Chiodini, Renato Bassan, Tiziano Barbui
      Pages 313-324
    12. E. G. Haarman, G. J. L. Kaspers, R. Pieters, C. H. van Zantwijk, G. J. Broekema, K. Hählen et al.
      Pages 325-333
    13. S. E. Balkham, J. M. Sargent, A. W. Elgie, C. J. Williamson, C. G. Taylor
      Pages 335-340
    14. Marián Hajdúch, Libor Havlíèek, Jaroslav Veselý, Radko Novotný, Vladimír Mihál, Miroslav Strnad
      Pages 341-353
    15. Valérie Palissot, Aurélie Trussardi, Marie-Claude Gorisse, Jean Dufer
      Pages 355-363
    16. Rajae Belhoussine, Hamid Morjani, Reynald Gillet, Valérie Palissot, Michel Manfait
      Pages 365-381
  4. Risk Factors and Cell Culture Assays

    1. R. Pieters, G. J. L. Kaspers, N. L. Ramakers-van Woerden, M. L. den Boer, M. G. Rots, Ch. M. Zwaan et al.
      Pages 391-395
    2. Alexandra Wagner, Georg Hempel, H. G. Gumbinger, Heribert Jürgens, Joachim Boos
      Pages 397-407
    3. Yaddanapudi Ravindranath, Jeffrey W. Taub
      Pages 409-414
    4. G. J. L. Kaspers, Ch. M. Zwaan, R. Pieters, A. J. P. Veerman
      Pages 415-421
    5. Britt-Marie Frost, Rolf Larsson, Peter Nygren, Gudmar Lönnerholm
      Pages 423-428
    6. Gudmar Lönnerholm, Britt-Marie Frost, Rolf Larsson, E. Liliemark, Peter Nygren, Curt Peterson
      Pages 429-435
    7. Peter Staib, Bernd Lathan, Timo Schinköthe, Sabine Wiedenmann, Bernhard Pantke, Thomas Dimski et al.
      Pages 437-444
    8. N. Stute, T. Köhler, L. Lehmann, W. Wetzstein, G. Ehninger
      Pages 445-452
    9. Zeynep Karakaş, Leyla Ağaoğlu, Serap Erdem, Sema Anak, Ayşegül Hacıbektaşoğlu, Gündüz Gedikoğlu
      Pages 453-459

About this book


Cellular drug resistance is a major limitation to the success of chemotherapy of leu­ kemia and lymphoma. The importance of this has now been recognized by both clinicians and scientists. It is of utmost importance to bridge the gap between laboratory and clinic in this field of research. This is the main purpose of the series of International Symposia on Drug Resistance in Leukemia and Lymphoma. These are held every three years in Am­ sterdam, The Netherlands, since 1992. This book contains the proceedings of the third of these meetings, organised in 1998. The book covers all important aspects of drug resistance in leukemia and lymphoma, both in the form of extensive reviews as in manuscripts describing original data. General mechanisms of resistance are discussed, including the drug resistance related proteins p­ glycoprotein, MRP (multi-drug resistance protein) and LRP (lung resistance protein), and the role of glutathione and glutathione-S-transferases. Moreover, more drug type-specific mechanisms of resistance are a topic, such as for glucocorticoids and antifolates. Much in­ formation is provided on apoptosis and its regulators, and on the results of cell culture drug resistance assays. Several papers focus on the modulation or circumvention of drug resistance.


Antigen apoptosis chemotherapy drug drug resistance imaging interferon leukemia lymphoma pathogenesis pharmacokinetics pharmacology proteins resistance tumor

Editors and affiliations

  • G. J. L. Kaspers
    • 1
  • R. Pieters
    • 1
  • A. J. P. Veerman
    • 1
  1. 1.University Hospital Vrije UniversiteitAmsterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1999
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-7180-9
  • Online ISBN 978-1-4615-4811-9
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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