© 2000

Elastic Filaments of the Cell

  • Henk L. Granzier
  • Gerald H. Pollack

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 481)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Elastic Filaments of The Cell

    1. Front Matter
      Pages 1-1
    2. Károly Trombitás
      Pages 1-23
    3. Koscak Maruyama, Sumiko Kimura
      Pages 25-33
    4. Thomas Centner, Francoise Fougerousse, Alexandra Freiburg, Christian Witt, Jacque S. Beckmann, Henk Granzier et al.
      Pages 35-52
    5. Marion L. Greaser, Seu-Mei Wang, Mustapha Berri, Paul Mozdziak, Yashiyuki Kumazawa
      Pages 53-66
    6. Abigail S. McElhinny, Siegfried Labeit, Carol C. Gregorio
      Pages 67-88
    7. Joseph W. Sanger, Joseph C. Ayoob, Prokash Chowrashi, Daniel Zurawski, Jean M. Sanger
      Pages 89-110
  3. Molecular Mechanism of Elasticity

    1. Front Matter
      Pages 111-111
    2. Miklós S. Z. Kellermayer, Steven Smith, Carlos Bustamante, Henk L. Granzier
      Pages 111-128
    3. Matthias Rief, Mathias Gautel, Hermann E. Gaub
      Pages 129-141
    4. Hui Lu, André Krammer, Barry Isralewitz, Viola Vogel, Klaus Schulten
      Pages 143-162
    5. Larissa Tskhovrebova, John Trinick
      Pages 163-178
  4. Titin-Like Proteins

    1. Front Matter
      Pages 207-207
    2. Belinda Bullard, David Goulding, Charles Ferguson, Kevin Leonard
      Pages 207-220
    3. Cristina Machado, Deborah J. Andrew
      Pages 221-236
    4. Agnes Ayme-Southgate, Richard Southgate, Michelle Kulp McEliece
      Pages 251-264
    5. Thomas C. S. Keller III, Kenneth Eilertsen, Mark Higginbotham, Steven Kazmierski, Kyoung-Tae Kim, Michaella Velichkova
      Pages 265-281

About this book


Elastic filaments refer mainly to titin, the largest of all known proteins. Titin was discovered initially in muscle cells, where it interconnects the thick filament with the Z-line. Titin forms a molecular spring that is responsible for maintaining the structural integrity of contracting muscle, ensuring efficient muscle contraction. More recently, it has become clear that titin is not restricted to muscle cells alone. For example, titin is found in chromosomes of neurons and also in blood platelets. This topic is fast becoming a focal point for research in understanding viscoelastic properties at the molecular, cellular, and tissue levels. In titin may lie a generic basis for biological viscoelasticity. It has become clear that titin may hold the key to certain clinical anomalies. For example, it is clear that titin-based ventricular stiffness is modulated by calcium and that titin is responsible for the altered stiffness in cardiomyopathies. It is also clear from evidence from a group of Finnish families that titin mutations may underlie some muscular dystrophies and that with other mutations chromatids fail to separate during mitosis. Thus, it is clear that this protein will have important clinical implications stemming from its biomechanical role. One aspect of this field is the bringing together of bioengineers with clinical researchers and biologists. Genetic and biochemical aspects of titin-related proteins are being studied together with front-line engineering approaches designed to measure the mechanics of titin either in small aggregates or in single molecules.


Activation Calcium Drosophila cell chromosome mutation protein protein structure proteins tissue

Editors and affiliations

  • Henk L. Granzier
    • 1
  • Gerald H. Pollack
    • 2
  1. 1.Washington State UniversityPullmanUSA
  2. 2.University of WashingtonSeattleUSA

Bibliographic information

  • Book Title Elastic Filaments of the Cell
  • Editors H.L. Granzier
    Gerald H. Pollack
  • Series Title Advances in Experimental Medicine and Biology
  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2000
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-306-46410-2
  • Softcover ISBN 978-1-4613-6916-5
  • eBook ISBN 978-1-4615-4267-4
  • Series ISSN 0065-2598
  • Edition Number 1
  • Number of Pages IX, 425
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Biochemistry, general
    Veterinary Medicine/Veterinary Science
  • Buy this book on publisher's site
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