Pain and Neuroimmune Interactions

  • Nayef E. Saadé
  • A. Vania Apkarian
  • Suhayl J. Jabbur

Table of contents

  1. Front Matter
    Pages i-x
  2. Nociceptors and Proinflammatory Mediators

    1. Front Matter
      Pages 1-1
    2. Sergio H. Ferreira, Daniela Sachs, Fernando Q. Cunha, B. B. Lorenzetti
      Pages 3-8
    3. Fernando Cervero, Jennifer M. A. Laird
      Pages 21-29
    4. Stephen Poole, Fernando de Queiroz Cunha, Sergio Henriques Ferreira
      Pages 31-54
  3. Hyperalgesia: Peripheral and Central Mechanisms

    1. Front Matter
      Pages 55-55
    2. Bengt Linderoth, Jian-Guo Cui, Vadym Yakhnitsa, T.-J. Sten Shi, Carl-Olav Stiller, William T. O’Connor et al.
      Pages 57-68
    3. Nicolas Danziger, Daniel Le Bars, Didier Bouhassira
      Pages 69-78
    4. William D. Willis, J. Wu, Qing Lin
      Pages 99-110
    5. Nayef E. Saadé, Cynthia A. Massaad, Salim A. Kanaan, Bared Safieh-Garabedian, Suhayl J. Jabbur, Samir F. Atweh
      Pages 111-123
  4. Pain and Central Neuroimmune Mechanisms

    1. Front Matter
      Pages 125-125
    2. Mireille Dardenne, Bared Safieh-Garabedian, Jean-Marie Pleau
      Pages 127-137
    3. Bared Safieh-Garabedian, Salim A. Kanaan, Suhayl J. Jabbur, Samir F. Atweh, Nayef E. Saadé
      Pages 139-147
    4. Hugo O. Besedovsky, Fernando Pitossi, Detlev Balschun, Horst Schneider, Adriana del Rey
      Pages 149-155
    5. France Haour, Eleni Dicou
      Pages 157-169
    6. T. Hori, T. Oka, M. Hosoi, M. Abe, K. Oka
      Pages 171-189
  5. Pain Consciousness and Limbic Mechanisms

    1. Front Matter
      Pages 191-191
    2. Ronald R. Tasker
      Pages 209-222
    3. Suhayl J. Jabbur, Nayef E. Saadé, Samir F. Atweh
      Pages 223-232
  6. Back Matter
    Pages 239-244

About this book


For those of us involved in research on the neural mechanisms that relate tissue damage to pain. it is becoming more evident that the sensation of pain and suffering could be considered as part of a mechanism that involves not only sizeable areas in the brain but also simultaneous activations of the immune and the endocrine systems as well. A consensus is growing among specialists in the field that pain involves the sharing of molecular mechanisms between the nervous, immune and endocrine systems that can interact at peripheral and, ultimately, central levels. Furthermore, chronic pain could then be looked upon as a corollary of the imbalance in the cross talk between these systems, which could lead to new treatment strategies. The aim of this book is not to deal with acute pain that serves as an alarm signal, but to attempt to explain the molecular mechanisms of chronic pains considered as a multifactorial syndrome or disease.


Arthritis Nervous System Peptide Syndrom immune system inflammation neural mechanisms tissue

Editors and affiliations

  • Nayef E. Saadé
    • 1
  • A. Vania Apkarian
    • 2
  • Suhayl J. Jabbur
    • 1
  1. 1.American University of BeirutBeirutLebanon
  2. 2.SUNY Health Science CenterSyracuseUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic/Plenum Publishers, New York 2000
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6897-7
  • Online ISBN 978-1-4615-4225-4
  • Buy this book on publisher's site
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