Immunology of Milk and the Neonate

  • Jiri Mestecky
  • Claudia Blair
  • Pearay L. Ogra

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 310)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Breastfeeding and Maternal-Neonatal Interactions. Epidemiological Aspects of Breastfeeding

  3. Development of the Neonatal Immune System

    1. Mark G. Cleveland, Mary A. Bakos, Susan M. Hilton, Randall M. Goldblum
      Pages 41-49
    2. Itaru Moro, Ichiro Saito, Masatake Asano, Tomihisa Takahashi, Takashi Iwase
      Pages 51-57
    3. André Nahmias, Barbara Stoll, Ellen Hale, Chris Ibegbu, Harry Keyserling, Wendy Innis-Whitehouse et al.
      Pages 59-69
    4. Anthony R. Hayward, Jesse Groothuis
      Pages 71-76
    5. Demetris Kokinopoulos, Spyros Photopoulos, Natassa Varvarigou, Loanis Kafegidakis, Marietta Xanthou
      Pages 77-85
    6. Allan W. Cripps, Maree Gleeson, Robert L. Clancy
      Pages 87-92
  4. Function of Cytokines in the Development of the Immune System

    1. Armond S. Goldman, Helen E. Rudloff, Frank C. Schmalstieg
      Pages 93-97
    2. Otakar Koldovský, John Britton, Diane Davis, Thomas Davis, Judy Grimes, Wuyi Kong et al.
      Pages 99-105
    3. Shu-heh W. Chu, W. Allan Walker
      Pages 107-112
    4. Jerry R. McGhee, Kohtaro Fujihashi, Cummins Lue, Kenneth W. Beagley, Jiri Mestecky, Hiroshi Kiyono
      Pages 113-121
    5. Jiri Mestecky, Zina Moldoveanu, Shirley J. Prince, William H. Kutteh, Rose Kulhavy, Jerry R. McGhee et al.
      Pages 123-129
  5. Innate Immune Factors

    1. Kenneth M. Pruitt, Firoz Rahemtulla, Britta Månsson-Rahemtulla, David C. Baldone, George T. Laven
      Pages 137-144
    2. Catharina Svanborg, Gustaf Aniansson, Jiri Mestecky, Hemant Sabharwal, Agnes Wold
      Pages 167-171
  6. Specific Immune Factors

    1. Shai Ashkenazi, David S. Newburg, Thomas G. Cleary
      Pages 173-177
    2. Marian Neutra, Richard Weltzin, Louis Winner, Julie Mack, Pierre Michetti, Lynda Morrison et al.
      Pages 179-182
    3. Pierre Michetti, Robert Hirt, Richard Weltzin, Nicholas Fasel, Esther Schaerer, Marian R. Neutra et al.
      Pages 183-185
    4. Michael E. Lamm, Janet K. Robinson, C. Koteswara Rao, Jean-Pierre Vaerman, Charlotte S. Kaetzel
      Pages 187-191
    5. José R. Cruz, Floridalma Cano, Patricia Cáceres
      Pages 193-199
    6. Francoise Mascart-Lemone, Philippe Donnen, Bahwere Paluku, Daniel Brasseur, Jeanine Van den Broeck, Jean-Pierre Vaerman et al.
      Pages 201-206
    7. Margaret A. Keller, Carol J. Palmer, Marie T. Jelonek, Charles H. Song, Alexander Miller, Eli E. Sercarz et al.
      Pages 207-213
    8. Pankaj D. Mehta, Charles E. Isaacs, Patricia K. Coyle
      Pages 223-226
  7. Antiviral Immunity

    1. Frances D. Gillin, Robert W. Cooper, David S. Reiner, Siddhartha Das
      Pages 227-233
    2. Roger I. Glass, Donna J. Ing, Barbara J. Stoll, Roy T. Ing
      Pages 249-254
    3. Albert Z. Kapikian, Jorge Flores, Timo Vesikari, Tarja Ruuska, H. Paul Madore, Kim Y. Green et al.
      Pages 255-264
    4. Genevive A. Losonsky, Haydee D’Alessandra de Rimer
      Pages 265-269
    5. Christopher F. Cuff, Christopher K. Cebra, Ehud Lavi, Eric H. Molowitz, Donald H. Rubin, John J. Cebra
      Pages 307-315
  8. Antibacterial Immunity

    1. Christopher T. Cordle, Joseph P. Schaller, Timothy R. Winship, Edrick L. Candler, Milo D. Hilty, K. Larry Smith et al.
      Pages 317-327
    2. Barry M. Gray, Rutherford B. Polhill Jr., David W. Reynolds
      Pages 337-344
    3. Leonard E. Weisman, F. Moncrief Dobson
      Pages 345-351
    4. Andrew G. Plaut, Jiazhou Qiu, Frank J. Grundy, Andrew Wright
      Pages 353-359
    5. Mary Boesman-Finkelstein, Richard A. Finkelstein
      Pages 361-367
    6. Thomas G. Cleary, Karen Hyani, Donald K. Winsor, Guillermo Ruiz-Palacios
      Pages 369-373
    7. Esther J. Israel, Edvardo J. Schiffrin, Edward A. Carter, Esther Frieberg, W. Allan Walker
      Pages 375-380

About this book


In the course of history, humans have attempted to interrupt the physiological and psychological bond formed between a nursing mother and her child by substituting breastfeeding with artificial formulas. A growing body of evidence indicates that breast milk, quite apart from its unsurpassed nutritive value, contains a large number of substances that protect the offspring from common infectious agents and allergens and promote the maturation of the gastrointestinal tract and the immune system. In addition to well described milk antibodies and soluble mediators of innate immunity, milk cells and pluripotent secreted factors - cytokines - are currently in the forefront of extensive research with respect to their importance in milk immunology. The purpose of this conference was to critically evaluate the current state of our knowledge concerning the protective role of immune agents found in milk, to provide up-to-date information of milk factors with respect to their role in the maturation of immunological defense systems in the neonate, and to reassess the importance of breastfeeding in the prevention of allergies in formula-fed infants. We hope that the work presented by international participants will prompt many new ideas and stimulate further research in this important area. This conference was sponsored primarily by the National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD. We would like to thank Drs. Sumner Yaffe and Delbert Dayton for their efforts with the organization, planning, and support of this conference.


Allergie antibody child cytokine cytokines development immune system immunology innate immunity nursing system

Editors and affiliations

  • Jiri Mestecky
    • 1
  • Claudia Blair
    • 2
  • Pearay L. Ogra
    • 3
  1. 1.University of Alabama at BirminghamBirminghamUSA
  2. 2.National Institutes of HealthBethesdaUSA
  3. 3.University of TexasGalvestonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1991
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6713-0
  • Online ISBN 978-1-4615-3838-7
  • Series Print ISSN 0065-2598
  • Series Online ISSN 2214-8019
  • Buy this book on publisher's site
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