Recombinant Technology in Hemostasis and Thrombosis

  • Leon W. Hoyer
  • William N. Drohan

Table of contents

  1. Front Matter
    Pages i-viii
  2. Characterization of Gene and Protein Structure

    1. Front Matter
      Pages 1-1
    2. Jan A. van Mourik, Anja Leyte, Harm B. van Schijndel, Martin Ph. Verbeet, Jan Voorberg, Ruud D. Fonteijn et al.
      Pages 3-12
    3. D. B. C. Ritchie, D. L. Robertson, R. T. A. MacGillivray
      Pages 13-24
    4. Paula R. Boerger, Robert M. Wolcott, Morgan Lorio, Michael N. Blackburn
      Pages 47-63
    5. Frederick J. Walker
      Pages 79-98
  3. Molecular Defects Affecting Hemostasis

    1. Front Matter
      Pages 99-99
    2. Leon W. Hoyer
      Pages 101-113
    3. Arthur R. Thompson
      Pages 115-131
    4. W. P. Sheffield, F. Fernandez-Rachubinski, R. C. Austin, M. A. Blajchman
      Pages 133-146
  4. Protein Production by Recombinant Technology

    1. Front Matter
      Pages 169-169
    2. Randal J. Kaufman, Robert J. Wise, Louise C. Wasley, Andrew J. Dorner
      Pages 171-185
    3. Rekha Paleyanda, Janet Young, William Velander, William Drohan
      Pages 197-209
  5. Clinical Use of Proteins Produced by Recombinant Technology

    1. Front Matter
      Pages 211-211
    2. Gilbert C. White II, Campbell W. McMillan, Edward D. Gomperts, Joseph E. Addiego Jr., Hans H. Brackmann, Doreen B. Brettler et al.
      Pages 235-241
  6. Concluding Overview

  7. Back Matter
    Pages 251-261

About this book


Recent progress in molecular biology has led to a rapid expansion of our understanding of the proteins that are essential for hemostasis and thrombosis. The goal of the XXI Annual Scientific Symposium of the American Red Cross was to provide a forum to explore and document the impact of recombinant DNA technology in this field. The speakers described the essential features of the genes responsible for key plasma proteins important in hemostasis, including procoagulant Factors VIII and IX and anticoagulant proteins, Antithrombin III and Protein C. They emphasized the advances in recombinant DNA technology that have led to the cloning of these genes. Careful examination of the gene sequence has then provided a clearer understanding of the structure of the encoded proteins, and has given additional insight into their functional domains and their interactions in hemostasis. At the same time, these advances have made it possible to better characterize hemostatic disorders. A large number of published studies have shown that the mutations affecting biological activity are clustered in areas that define functional domains. They have led to fundamental advances in our understanding of specific diseases and they have made it possible to develop more accurate and sensitive diagnostic tests for the detection of the disease states.


DNA biology genes molecular biology mutation plasma protein proteins thrombosis

Editors and affiliations

  • Leon W. Hoyer
    • 1
  • William N. Drohan
    • 1
  1. 1.Jerome H. Holland LaboratoryAmerican Red Cross Blood ServicesRockvilleUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology