The Biology and Prevention of Aerodigestive Tract Cancers

  • Guy R. Newell
  • Waun Ki Hong

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 320)

Table of contents

  1. Front Matter
    Pages i-x
  2. Margaret R. Spitz, T. C. Hsu, Stimson P. Schantz
    Pages 31-34
  3. Richard C. Moon, Kandala V. N. Rao, Carol J. Detrisac, Gary J. Kelloff
    Pages 55-61
  4. Irma B. Gimenez-Conti, Thomas J. Slaga
    Pages 63-67
  5. Thomas E. Carey, Leena Laurikainen, Angelika Ptok, Timothy Reinke, Keith Linder, Thankam S. Nair et al.
    Pages 69-79
  6. James L. Mulshine, Michael Birrer, Anthony M. Treston, Frank Scott, Kathryn Quinn, Ingalill Avis et al.
    Pages 81-88
  7. Susan Taylor Mayne, Tongzhang Zheng, Dwight T. Janerich, W. Jarrard Goodwin Jr., Barbara G. Fallon, Dennis L. Cooper et al.
    Pages 119-127
  8. Scott M. Lippman, Waun Ki Hong
    Pages 151-161
  9. Back Matter
    Pages 163-172

About this book


The papers contained in this volume were presented ati the Golden Jubilee Cancer Prevention Conference, "The Biology and Prevention of Aerodigestive Tract Cancers," sponsored by The University of Texas M. D. Anderson Cancer Center in Houston, Texas, February 21-23, 1991. The purpose of the conference was to further the understanding of the biology, epidemiology, and prevention of aerodigestive tract cancers. Advances in under­ standing the biology of aerodigestive tract cancers have led to successful early chemoprevention trials. Chemopreventive agents in current use are capable 9f reversing premalignant lesions, as well as reducing the number of second primary cancers of the head and neck. These trials hold the promise that effective prevention methods for these cancers will be forthcoming in the foreseeable future. Carcinogenic exposures appear to affect the entiry epithelial lining of the upper aerodigestive tract, a phenomena described as "field cancerization. " This process contributes to the development of both synchronous and metachronous aerodigestive tract cancers. It also provides a sound rationale for the chemoprevention of these cancers. Animal models are important for identifying the critical components of field cancerization and for testing potentially new chemopreventive agents and regimens. The hamster lung carcinogen­ esis model and the hamster cheek model are discussed. Aerodigestive tract cancers account for about 20% of newly diagnosed invasive cancers. Cigarette smoking and alcohol consumption are the most important risk factors for these cancers.


cancer cancer prevention carcinogenesis carcinoma epidemiology esophagus etiology lung cancer prevention

Editors and affiliations

  • Guy R. Newell
    • 1
  • Waun Ki Hong
    • 1
  1. 1.The University of Texas M. D. Anderson Cancer CenterHoustonUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6536-5
  • Online ISBN 978-1-4615-3468-6
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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