© 1992

Innovations in Antiviral Development and the Detection of Virus Infections

  • Timothy M. Block
  • Donald Jungkind
  • Richard L. Crowell
  • Mark Denison
  • Lori R. Walsh

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 312)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Frank J. Dutko, Donald E. Baright, Guy D. Diana, M. Pat Fox, Daniel C. Pevear, Mark A. McKinlay
    Pages 15-24
  3. Robert H. Grafstrom, Katherine Zachariasewycz, Richard A. Brigandi, Timothy M. Block
    Pages 25-40
  4. Per Ashorn, Bernard Moss, Edward A. Berger
    Pages 71-81
  5. Y.-S. Edmond Cheng, Catherine E. Patterson, Ronald G. Rucker, Michael J. Otto, Christopher J. Rizzo, Bruce D. Korant
    Pages 83-88
  6. Vincent J. Merluzzi, Alan S. Rosenthal
    Pages 89-94
  7. Paul Martin, Lawrence S. Friedman
    Pages 111-120
  8. John L. Gerin, Brent E. Korba, Paul J. Cote, Bud C. Tennant
    Pages 121-123
  9. Edouard M. Cantin, Gregory Podsakoff, Dru E. Willey, Harry Openshaw
    Pages 139-149
  10. Emanuela Pelosi, Karen A. Hicks, Stephen L. Sacks, Donald M. Coen
    Pages 151-158
  11. Hsu-Tso Ho, Kathleen L. Woods, Sherry A. Konrad, Hilde De Boeck, Michael J. M. Hitchcock
    Pages 159-166
  12. Cindy Wordell, Lorena Chambers, Maryann Durante, Sue DiRenzo, Leigh Hopkins, Donald Jungkind
    Pages 173-182
  13. Stephen Lee, John McHutchinson, Brian Francis, Robert DiNello, Alan Polito, Stella Quan et al.
    Pages 183-189

About this book


THE ERA OF ANTIVIRALS Introduction Although there are more than one hundred medically useful antibiotics and fungicides, there are only seven compounds licensed for use as antiviral agents, in the USA. Some of these (acyclovir and ganciclovir) are actually derivatives of each other, making the number of new discoveries even smaller. Moreover, most of these agents are of only limited therapeutic value and have substantial toxicity. It has been more than 100 years ago since Pasteur studied rabies virus (2) and Rous (4) showed that a small filterable agent (not bacteria) caused disease (sarcoma) in chickens. It was nearly 100 years ago that yellow fever virus, the first recognized human pathogenic virus, was unambiguously associated with disease (3). Enteroviruses were cultured for the first time nearly 50 years ago (1). Why then has effective chemotherapy against viruses lagged behind that of other microorganisms? Viruses are often difficult to grow and image. However, with the dynamic advances in molecular biology and increased sophistication in tissue culture, the field of virology has blossomed and resulted in improved methods for detection of virus infection. The use of viruses as models of gene regulation and replication has also resulted in a massive accumulation of information.


antibiotics bacteria development infection infections microorganism tissue virus

Editors and affiliations

  • Timothy M. Block
    • 1
  • Donald Jungkind
    • 1
  • Richard L. Crowell
    • 2
  • Mark Denison
    • 3
  • Lori R. Walsh
    • 4
  1. 1.Thomas Jefferson University HospitalPhiladelphiaUSA
  2. 2.Hahnemann University School of MedicinePhiladelphiaUSA
  3. 3.Vanderbilt UniversityNashvilleUSA
  4. 4.Mercy Catholic Medical CenterDarbyUSA

Bibliographic information

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