Pancreatic Islet Cell Regeneration and Growth

  • Aaron I. Vinik
  • David J. Sirman

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 321)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Introduction

    1. Aaron I. Vinik
      Pages 1-5
  3. Regulation of Cell Growth and Development

    1. Front Matter
      Pages 7-7
    2. Jens Høiriis Nielsen, Annette Møldrup, Nils Billestrup, Elisabeth Douglas Petersen, Giovanna Allevato, Matthias Stahl
      Pages 9-20
    3. Derek LeRoith, Haim Werner, Bartolome Burguera, Charles T. Roberts Jr., Susan Mulroney, Aviad Haramati
      Pages 21-30
    4. Timothy J. Bos
      Pages 45-51
  4. Models for the Study of Cell Regeneration

    1. Front Matter
      Pages 59-59
    2. Michiaki Unno, Takako Itoh, Takuo Watanabe, Hikari Miyashita, Shigeki Moriizumi, Hiroshi Teraoka et al.
      Pages 61-69
    3. Ling Chen, Michael C. Appel, Tausif Alam, Chisato Miyaura, Andrea Sestak, John O’Neil et al.
      Pages 71-84
  5. Induction of Cell Growth and Mechanisms

  6. Pathogenetic and Therapeutic Ramifications

    1. Front Matter
      Pages 165-165
    2. Kenneth L. Luskey
      Pages 167-169
    3. Donald C. Dafoe, Xuegong Wang, Lorraine Tafra, Ronald Berezniak, Ricardo V. Lloyd
      Pages 171-177
  7. Back Matter
    Pages 179-187

About this book


Aaron I. Vinik, M.D., Ph.D. I IEastem Virginia Medical School The Diabetes Institutes Norfolk, Virginia 23510 This symposium, held in June 1991, was a gathering of international scientists to exchange their views on current concepts of cell growth and differentiation. Each scientist was asked to present a topic of their research related to cell growth and regeneration and to participate in a round table conference elaborating on current knowledge and sharing their experiences. By furthering this promising area of endeavor, a means of understanding ontogeny of cell development and of providing insights into tumor biology would prevail. Of prime importance was the anticipation that new information from a better understanding of the normal evolution of the pancreatic islet would generate alternative approaches to curing diabetes. This forward serves as a short introduction to the concept of pancreatic islet regeneration and the models currently in use to study the process. DEVELOPMENTAL ORIGIN OF ISLETS DURING EMRYOGENESIS The developing pancreas appears as a protrusion from the dorsal surface of the l embryonic gut. The different islet cell types appear sequentially during development in vivo. It therefore seems reasonable to propose that coordinated growth is dependent upon specificity of growth factors.


Diabetes Pancreas biology development evolution growth factor tumor

Editors and affiliations

  • Aaron I. Vinik
    • 1
  • David J. Sirman
  1. 1.The Diabetes InstitutesEastern Virginia Medical SchoolNorfolkUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6526-6
  • Online ISBN 978-1-4615-3448-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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