Neurobiology of Essential Fatty Acids

  • Nicolas G. Bazan
  • Mary G. Murphy
  • Gino Toffano

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 318)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Phospholipases A2: Properties and Modulation

    1. H. van den Bosch, C. Schalkwijk, J. Pfeilschifter, F. Märki
      Pages 1-10
    2. Akhlaq A. Farooqui, Yutaka Hirashima, Lloyd A. Horrocks
      Pages 11-25
    3. Makoto Murakami, Ichiro Kudo, Keizo Inoue
      Pages 27-34
    4. Edward A. Dennis, Raymond A. Deems, Lin Yu
      Pages 35-39
    5. Bo K. Siesjö, Kenichiro Katsura
      Pages 41-56
  3. Cell Signaling and Essential Fatty Acids: Cross-Talk between Receptors and Messengers

  4. Metabolites of Essential Fatty Acids and other Membrane-Derived Second Messengers in Cell Signaling

    1. A. Volterra, D. Trotti, P. Cassutti, C. Tromba, R. Galimberti, P. Lecchi et al.
      Pages 147-158
    2. Steven J. Feinmark, Douglas J. Steel, Anoopkumar Thekkuveettil, Mayumi Abe, Xiang-Duan Li, James H. Schwartz
      Pages 159-169
    3. E. B. Stubbs Jr., R. O. Carlson, C. Lee, S. K. Fisher, A. K. Hajra, B. W. Agranoff
      Pages 171-182
    4. Koji Abe, Tsutomu Araki, Jun-ichi Kawagoe, Masashi Aoki, Kyuya Kogure
      Pages 183-195
  5. Dietary Supply of Essential Fatty Acids, Synaptogenesis, and Photoreceptor Membrane Biogenesis

  6. Essential Fatty Acids, Excitable Membrane Phospholipids, and Pathophysiology

    1. R. E. Anderson, P. J. O’Brien, R. D. Wiegand, C. A. Koutz, A. M. Stinson
      Pages 285-294
    2. Michael A. Crawford
      Pages 307-314
    3. Ephraim Yavin, Baruch Kunievsky, Nicolas G. Bazan, Shaul Harel
      Pages 315-323
    4. A. Poulos, K. Beckman, D. W. Johnson, B. C. Paton, B. S. Robinson, P. Sharp et al.
      Pages 331-340
    5. R. A. Gibson, M. Makrides, K. J. Clark, M. A. Neumann, D. R. Lines
      Pages 341-345
    6. Tetsutaro Shinomura, Hiroyuki Mishima, Shinji Matsushima, Yoshinori Asaoka, Kimihisa Yoshida, Masahiro Oka et al.
      Pages 361-373
  7. Essential Fatty Acids and Excitable Membrane Phospholipids

    1. Pietro Palatini
      Pages 375-391
    2. Maria Grazia Nunzi, Diego Guidolin, Lucia Petrelli, Patrizia Polato, Adriano Zanotti
      Pages 393-398
    3. P. Kurian, L. J. Chandler, R. Patel, F. T. Crews
      Pages 399-411
  8. Back Matter
    Pages 427-444

About this book


It is increasingly evident that polyunsaturated fatty acids (PUFA), which in the past were often believed to be mere components of cellular membranes of neural tissue, are actually major determinants of the functional properties of neural cells and are intimately involved in brain disease processes. The two families of PUF A, which are derived from the essential polyenes, linoleic (18:26) and a-linolenic (18:33) acids, constitute a major proportion (-30%) of the total fatty acids esterified to brain phospholipids. Each family is distributed in membranes in a highly specific manner with respect to brain region, cell type, and position within each of the phosphoglycerides. Unlike their behavior in other organs, the PUF A components of brain turn over slowly and are relatively resistant to dietary modification. Their unique distribution and stability suggest that they play an important role in determining the functional properties of neural cells. However, until recently very little was known regarding the precise nature of their involvement.


GABA Glutamat behavior biology brain kinetics lipide neurobiology pathophysiology physiology receptor tissue

Editors and affiliations

  • Nicolas G. Bazan
    • 1
  • Mary G. Murphy
    • 2
  • Gino Toffano
    • 3
  1. 1.Louisiana State University Eye Center and Neuroscience Center Louisiana State University School of MedicineNew OrleansUSA
  2. 2.Dalhousie UniversityNova ScotiaCanada
  3. 3.FIDIA Research LaboratoriesAbano TermeItaly

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6515-0
  • Online ISBN 978-1-4615-3426-6
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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