© 1992

Prostate Cancer and Bone Metastasis

  • James P. Karr
  • Hidetoshi Yamanaka

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 324)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Prostatic Cancer Bone Metastasis: An International Perspective

    1. Kyoichi Imai, Takanori Suzuki, Toshihiro Shimizu, Hidetoshi Yamanaka, Hiroshi Kanetake, Hideki Sakai et al.
      Pages 29-38
  3. Biology

    1. Bruce R. Zetter, Marcela Chackal-Roy, Roy Smith
      Pages 39-43
    2. Martin I. Resnick
      Pages 77-81
    3. Masaoki Harada, Akio Shimizu, Yoshiyasu Nakamura, Ryosuke Nemoto
      Pages 83-92
    4. Yukiko Nishijima, Katsunori Uchida, Kenkichi Koiso, Ryosuke Nemoto
      Pages 93-100
    5. Yuhsi Matuo, Wallace L. McKeehan, Guo-Chen Yan, Stathis Nikolaropoulos, Pamela S. Adams, Yoshitatsu Fukabori et al.
      Pages 107-114
    6. Howard I. Scher, Tracy Curley, Samuel Yeh, William Tong, Paul V. O’Moore, Steven Larson
      Pages 115-129
  4. Models

    1. Tomoyuki Shirai, Seiko Tamano, Satoru Takahashi, Nobuyuki Ito
      Pages 151-158
    2. Kenkichi Koiso, Tatsuo Iizumi
      Pages 159-163
  5. Pathology

    1. David Goltzman, Isobel Bolivar, Shafaat A. Rabbani
      Pages 165-171
    2. Masaoki Harada, Man-ichi Iida, Masanao Yamaguchi, Keizo Shida
      Pages 173-182
    3. Satoru Kobayashi, Manabu Kuriyama, Naoki Yamamoto, Yoshito Takahashi, Ikuo Shinoda, Toshimi Takeuchi et al.
      Pages 183-188

About this book


The biology of solid tumor metastasis has been the subject of significant scientific and clinical interest for years and while experimental evidence reveals that metastasis is not solely a random event, very little is known about the biology of metastasis originating from prostate cancer. This is in spite of the fact that the majority of prostate cancer patients die with metastatic lesions to the bone. Progress in understanding this most important aspect of prostate cancer has been hampered by the lack of suitable animal models and an inability to accurately quantify bone metastases and their responses to therapy. Over the past decade, scientists in Japan and the United States have steadily advanced our understanding of the cellular, molecular and immunologic biology of primary and disseminated prostate cancer. It is this body of new information, combined with advances in imaging techniques and prostate cancer tumor markers, that prompted the need for an in-depth assessment of bone metastasis of prostate cancer. Accordingly, on December 12, 1990, a group of basic and clinical investigators from Japan and the United States convened in Gotenba, Japan, to hold the first conference devoted solely to the basic biology and clinical aspects of bone metastases originating from prostate cancer. The cross-fertilization of ideas that was fostered through in-depth discussion of technological advances among various basic and clinical disciplines not only further advanced our understanding of prostate metastases to the bone, but suggested approaches for precise quantitative assessment of these lesions and their treatment.


assessment cancer imaging imaging techniques metastasis prostate cancer therapy treatment tumor

Editors and affiliations

  • James P. Karr
    • 1
  • Hidetoshi Yamanaka
    • 2
  1. 1.Roswell Park Cancer InstituteBuffaloUSA
  2. 2.Gunma UniversityGunmaJapan

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology