Mechanisms of Lymphocyte Activation and Immune Regulation IV

1. B Cell Development, Activation, Proliferation, and Differentiation

   1. Role of Contact and Soluble Factors in the Growth and Differentiation of B Cells by Helper T Cells

      • Randolph J. Noelle, Lisa Marshall, Meenakshi Roy, David M. Shepherd, Ivan Stamenkovic, Jeffrey A. Ledbetter et al.

      Pages 131-138

   2. B-Cell Activation Mediated by Interactions with Membranes from Helper T Cells

      • Marilyn R. Kehry, Brian E. Castle, Philip D. Hodgkin

      Pages 139-148

   3. The Low Affinity IgE Fc Receptor (CD23) Participates in B Cell Activation

      • Thomas J. Waldschmidt, Lorraine T. Tygrett

      Pages 149-156

2. Adhesion Molecules: Structure, Regulation and Functions

   1. Front Matter

      Pages 157-157

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   2. T Cell Adhesion Cascades: General Considerations and Illustration with CD31

      • Yoshiya Tanaka, Stephen Shaw

      Pages 157-162

   3. Analyses of VLA-4 Structure and Function

      • Paul D. Kassner, Joaquin Teixido, Bosco M. C. Chan, Christina M. Parker, Martin E. Hemler

      Pages 163-170

   4. On the Regulation of β2 Integrins

      • M. Amin Arnaout, Masahiro Michishita, Chander P. Sharma

      Pages 171-179

   5. Leukocyte-Endothelial Cell Adhesion as an Active, Multi-Step Process: A Combinatorial Mechanism for Specificity and Diversity in Leukocyte Targeting

      • Eugene C. Butcher

      Pages 181-194

3. Back Matter

   Pages 195-204

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In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined.

• bone
• cells
• development
• plasma membrane
• tissue

• University of California, Irvine, USA

  Sudhir Gupta

• National Cancer Institute, National Institutes of Health, Bethesda, USA

  Thomas A. Waldmann

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