© 1992

Mechanisms of Lymphocyte Activation and Immune Regulation IV

Cellular Communications

  • Sudhir Gupta
  • Thomas A. Waldmann

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 323)

Table of contents

  1. Front Matter
    Pages i-ix
  2. T Cell Receptors and T Cell Activation

    1. Front Matter
      Pages 1-1
    2. Isaac Engel, Francois Letourneur, John T. B. Houston, Tom H. M. Ottenhoff, Richard D. Klausner
      Pages 1-7
    3. Lawrence E. Samelson, Mark Egerton, Pamela M. Thomas, Ronald L. Wange
      Pages 9-16
    4. Jeffrey A. Ledbetter, Peter S. Linsley
      Pages 23-27
    5. Ian S. Trowbridge, Pauline Johnson, Hanne Ostergaard, Nicholas Hole
      Pages 29-37
    6. Ethan M. Shevach
      Pages 49-55
    7. Thomas A. Waldmann, Carolyn Goldman, Lois Top, Angus Grant, Jack Burton, Richard Bamford et al.
      Pages 57-66
  3. T Cell Development

    1. Front Matter
      Pages 67-67
    2. David H. Raulet, Nan-Shih Liao, Isabel Correa, Mark Bix
      Pages 67-72
    3. Tak W. Mak, Amin Rahemtulla, Marco Schilham, Dow Rhoon Koh, Wai Ping Fung-Leung
      Pages 73-77
    4. Nicolai S. C. van Oers, Alex M. Garvin, Michael P. Cooke, Craig B. Davis, D. R. Littman, Roger M. Perlmutter et al.
      Pages 89-99
    5. Ada M. Kruisbeek, John D. Nieland, Lori A. Jones
      Pages 101-109
  4. B Cell Development, Activation, Proliferation, And Differentiation

    1. Front Matter
      Pages 111-111
    2. Kenneth Dorshkind, Ramaswamy Narayanan, Kenneth S. Landreth
      Pages 119-123
    3. Linda S. Park, Philip J. Morrissey, Barry Davison, Kenneth Grabstein
      Pages 125-129

About this book


In recent years rapid progress has been made in the areas of T cell and B cell biology, cell-cell and cell-matrix/stroma interactions. The use of isolated subunits of the T cell receptor invariant chains has been instrumental in defining their role in signal transduction and tyrosine phosphorylation. A role of src family phosphotyrosine kinases in T cell activation has been demonstrated and several phosphotyrosine kinase substrates have been identified and their functions characterized. Homologous recombinant techniques have led to the development of murine strains that lack CD4 or CD8 expression. These models are likely to be instrumental in studying the role of T cell subsets in autoimmune disorders, tissue transplant rejection and tumor rejection. A role of major histocompatibility complex I in the development of T cell subsets and NK cells has been defined. Recent data suggest a role of interaction between plasma membrane molecules of activated T helper cells and B cells, B cells primed with plasma membrane of activated T helper cells and cytokines, and interaction between bone marrow stromal cells and B cell progenitors and precursors, in the B cell development, proliferation, and differentiation. The structure and functions of adhesion molecules, especially with regard to signal transduction and homing events, are better defined.


bone cells development plasma membrane tissue

Editors and affiliations

  • Sudhir Gupta
    • 1
  • Thomas A. Waldmann
    • 2
  1. 1.University of CaliforniaIrvineUSA
  2. 2.National Cancer InstituteNational Institutes of HealthBethesdaUSA

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