Ion Channels

  • Toshio Narahashi

Part of the Ion Channels book series (IC)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Daniel Johnston, Ronald Fisher, Richard Gray
    Pages 39-62
  3. Steven F. Stasheff, Wilkie A. Wilson
    Pages 137-157
  4. C. Collin, D. L. Alkon
    Pages 159-175
  5. C. G. Caratsch, F. Grassi, F. Eusebi
    Pages 177-206
  6. Chun-Fang Wu, Barry Ganetzky
    Pages 261-314
  7. Robert L. Macdonald, Roy E. Twyman
    Pages 315-343
  8. Back Matter
    Pages 345-350

About this book


In the past few years, the scientific community has witnessed significant progress in the study of ion channels. Technological advancement in biophysics, molecular biology, and immunology has been greatly ac­ celerated, making it possible to conduct experiments which were deemed very difficult if not impossible in the past. For example, patch-clamp techniques can now be used to measure ionic currents generated by almost every type of cell, thereby allowing us to analyze whole-cell and single­ channel events. It is now possible to incorporate purified ion channel components into lipid bilayers to reconstitute an "excitable membrane." Gene cloning and monoclonal antibody techniques provide us with new approaches to the study of the molecular structure of ion channels. A variety of chemicals have now been found to interact with ion channels. One of the classical examples is represented by tetrodotoxin, a puffer fish poison, which was shown in the early 1960s to block the voltage-activated sodium channel in a highly specific and potent manner.


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Editors and affiliations

  • Toshio Narahashi
    • 1
  1. 1.Northwestern University Medical SchoolChicagoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 1992
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6466-5
  • Online ISBN 978-1-4615-3328-3
  • Buy this book on publisher's site