© 1992


  • Yousef Al-Doory
  • Arthur F. DiSalvo

Part of the Current Topics in Infectious Disease book series (CTID)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Yousef Al-Doory
    Pages 1-7
  3. Elmer Brummer
    Pages 31-42
  4. Arthur F. DiSalvo
    Pages 43-73
  5. Arthur F. DiSalvo
    Pages 75-104
  6. Norman L. Goodman
    Pages 105-121
  7. Leo Kaufman
    Pages 123-132
  8. Bruce S. Klein
    Pages 133-163
  9. William A. Causey, Guy D. Campbell
    Pages 165-188
  10. Francis W. Chandler, John C. Watts
    Pages 189-220
  11. George C. Cozad
    Pages 221-235
  12. Robert W. Bradsher
    Pages 237-247
  13. Alfred M. Legendre
    Pages 249-264
  14. Back Matter
    Pages 265-268

About this book


Blastomycosis remains the most enigmatic of human mycotic infections. The enigmas encompass the natural habitat of the etiologic agent, extent of exposure and subclinical infections in endemic areas, distribution of en­ demic foci throughout the world, inconsistency of serologic evaluation of infected patients, and varying response of such patients to standard treat­ ment regimens. In spite of diligent investigations by many competent investigators, we still do not know the ecological niche inhabited by the etiologic agent. We have many tantalizing clues but no definite answers. Nor do we know the extent of the endemic areas in the world for this disease. Skin testing, so useful in defining the distribution of histoplasmosis and coccidioidomycosis, has been of no value in mapping endemic areas for blastomycosis. Even the serologic evaluation of known cases of the disease has been too erratic in results to be useful as a diagnostic or prognostic procedure. The enigmas of blastomycosis go straight to the disease itself. There is an extensive literature on the debate concerning the presence and extent of subclinical infections. Case report series demonstrate that such transient infections do occur but, unlike other mycoses, the extent to which this phe­ nomenon is common in the general population still cannot be assessed. Even the diagnosis of established disease is a major clinical problem.


diagnosis epidemiology immunology therapy

Editors and affiliations

  • Yousef Al-Doory
    • 1
  • Arthur F. DiSalvo
    • 2
  1. 1.School of Medicine and Health SciencesGeorge Washington UniversityUSA
  2. 2.Nevada State Health LaboratoryRenoUSA

Bibliographic information

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Internal Medicine & Dermatology