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Growth Factors and the Cardiovascular System

  • Peter Cummins

Part of the Developments in Cardiovascular Medicine book series (DICM, volume 147)

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Carl-Henrik Heldin, Lena Claesson-Welsh, Kohei Miyazono, Bengt Westermark
    Pages 1-15
  3. Peter Cummins, Abdel-Ilah K. El Amrani, Francine El Amrani
    Pages 17-30
  4. Lydie Rappaport, Jane Lise Samuel
    Pages 31-43
  5. Elissavet Kardami, Raymond R. Padua, Kishore Babu S. Pasumarthi, Lei Liu, Bradley W. Doble, Sarah E. Davey et al.
    Pages 55-75
  6. Michael D. Schneider, Thomas Brand, Robert J. Schwartz, W. Robb MacLellan
    Pages 77-103
  7. Bruce I. Goldman, John Wurzel
    Pages 105-117
  8. Hari S. Sharma, Rene Zimmerman
    Pages 119-148
  9. Robert J. Schott, Linda A. Morrow
    Pages 149-168
  10. Gordon A. A. Ferns, Claire Rutherford
    Pages 169-187
  11. Peter L. Weissberg, D. J. Grainger, James C. Metcalfe
    Pages 189-206
  12. Andrew C. Newby, Nicholas P. J. Brindle
    Pages 207-225
  13. Ward Casscells, Douglas A. Lappi, Andrew Baird
    Pages 227-248
  14. Abdel-Ilah K. El Amrani, Francine El Amrani, Peter Cummins
    Pages 287-310
  15. Carlin S. Long, Paul C. Simpson
    Pages 321-335
  16. Rosemary J. Akhurst, Marion Dickson, Fergus A. Millan
    Pages 347-366
  17. Back Matter
    Pages 367-370

About this book

Introduction

Nature is totally amoral! There are at least 3-4 million people in France alone who suffer from arterial hypertension, and whose cardiovascular system is submitted day and night to both a haemodynamic and hormonal stress. In all cases, the vasculature hypertrophies as does the myocardium. This growth process is obviously mainly detrimental at the outset since it lowers compliance of the arteries and makes them stiffer. In contrast, myocardial hypertrophy is initially beneficial since the growth process multiplies the number of contractile units and by so doing improves external work. In addition, according to Starling's law, wall stress is lowered. Growth factors playa major role in this amoral process as a trigger for hypertrophy at the vascular level, and very likely at the level of the myocardium. Another major point of interest is the role of growth factors as determinants of restenosis after angioplasty and also of atherogenesis. Several chapters in this book are directly or indirectly concerned with this problem which is far from being purely academic since several groups are currently trying to control these processes by gene transfer. Certainly, one of the major clinical questions arising from such studies is why restenosis is not more frequent in clinical practice. After de-endotheliazation, the biologist would predict on the basis of recent studies on growth factors, and in contrast with current clinical opinion, that hypertrophy would occur in all cases with more or less complete restenosis.

Keywords

angiogenesis atherosclerosis cardiovascular cardiovascular system cell growth heart smooth muscle vascular disease

Editors and affiliations

  • Peter Cummins
    • 1
  1. 1.Department of PhysiologyUniversity of Birmingham School of MedicineBirminghamUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-3098-5
  • Copyright Information Kluwer Academic Publishers 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6354-5
  • Online ISBN 978-1-4615-3098-5
  • Series Print ISSN 0166-9842
  • Buy this book on publisher's site
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