Mechanisms of Platelet Activation and Control

  • Kalwant S. Authi
  • Steve P. Watson
  • Vijay V. Kakkar

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 344)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Lawrence F. Brass, James A. Hoxie, Thomas Kieber-Emmons, David R. Manning, Mortimer Poncz, Marilyn Woolkalis
    Pages 17-36
  3. Yoshinori Nozawa, Yoshiko Banno, Koh-ichi Nagata
    Pages 37-47
  4. Eduardo G. Lapetina, Francis X. Farrell
    Pages 49-55
  5. Stewart O. Sage, Paul Sargeant, Johan W. M. Heemskerk, Martyn P. Mahaut-Smith
    Pages 69-82
  6. Maurice B. Feinstein, Kevin Pumiglia, Lit-Fui Lau
    Pages 129-148
  7. Gérard P. Mauco, Claire Sultan, Bernard Payrastre, Monique Plantavid, Monique Breton, Hugues Chap
    Pages 165-174
  8. Gilbert C. White II, Neville Crawford, Thomas H. Fischer
    Pages 187-194
  9. Edouard M. Bevers, Paul Comfurius, Robert F. A. Zwaal
    Pages 195-207
  10. J. M. Gerrard, S. P. Saxena, A. McNicol
    Pages 209-219
  11. J. Michael Wilkinson, Edward J. Hornby, Kalwant S. Authi
    Pages 221-228
  12. Ulrich Walter, Martin Eigenthaler, Jörg Geiger, Matthias Reinhard
    Pages 237-249
  13. Marek W. Radomski, Salvador Moncada
    Pages 251-264
  14. Back Matter
    Pages 265-272

About this book


Recent years have seen tremendous advances in our understanding of the molecular mechanism of platelet activation. All aspects of signal transduction in platelets from the identification of surface receptors, G proteins, phospholipases, protein kinases and phosphatases, intracellular receptors for inositol phosphates, the Ca2+ regulatory machinery, cytoskeletal constituents to the control mechanism employing cyclic nucleotides has seen an explosion of information regarding their importance and for each constituent in the family of molecules to which they belong. This information has been of interest to researchers across a wide spectrum of disciplines including biochemists, pharmacologists, cell biologists and clinicians. In April 1992 an International Symposium bearing the name of this volume was organised at the Thrombosis Research Institute to bring together scientists from across the world whose common interest was the study of platelet activation and its regulation. We were particularly encouraged by the positive response from our speakers and the participants, their detailed contributions and the very lively discussions that took place throughout the two days of the symposium. Almost every aspect of signal transduction in human platelets was represented. Of the invited speakers twelve were from Europe (including the U. K. ), eight from North America and one from Japan. This volume is a compilation of chapters submitted by the speakers and represents a concise but informative picture of the present knowledge of the mechanisms of platelet activation and control.


Nucleotide protein proteins receptor research

Editors and affiliations

  • Kalwant S. Authi
    • 1
  • Steve P. Watson
    • 2
  • Vijay V. Kakkar
    • 1
  1. 1.Thrombosis Research InstituteLondonUK
  2. 2.University of OxfordOxfordUK

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6304-0
  • Online ISBN 978-1-4615-2994-1
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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