Current Directions in Insulin-Like Growth Factor Research

  • Derek Le Roith
  • Mohan K. Raizada

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 343)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Martin L. Adamo, Stefan Neuenschwander, Derek LeRoith, Charles T. Roberts Jr.
    Pages 1-11
  3. Jennifer M. Pell, R. Stewart Gilmour
    Pages 13-23
  4. Lawrence J. Slieker, Gerald S. Brooke, Ronald E. Chance, Li Fan, James A. Hoffmann, Daniel C. Howey et al.
    Pages 25-32
  5. Leon A. Bach, Susan Hsieh, Katsu-ichi Sakano, Hiroyuki Fujiwara, James F. Perdue, Matthew M. Rechler
    Pages 55-61
  6. J. S. Sussenbach, R. J. T. Rodenburg, W. Scheper, P. Holthuizen
    Pages 63-71
  7. Carolyn A. Bondy, Edward Chin, Jian Zhou
    Pages 73-77
  8. Renato Baserga, Pierluigi Porcu, Michele Rubini, Christian Sell
    Pages 105-112
  9. Karen A. Seta, Kristina S. Kovacina, Richard A. Roth
    Pages 113-124
  10. Valerie M. Watt, Peter Shier, Joanne Chan, Bradley A. Petrisor, Swarna K. Mathi
    Pages 125-132
  11. Steven A. Rosenzweig, Barry S. Oemar, Norman M. Law, Uma T. Shankavaram, Bradley S. Miller
    Pages 159-168
  12. Sonia M. Najjar, Neubert Philippe, Simeon I. Taylor, Domenico Accili
    Pages 169-174
  13. Wieland Kiess, Andreas Hoeflich, Yi Yang, Ulrike Kessler, Allan Flyvbjerg, Bruno Barenton
    Pages 175-188
  14. Constantin Polychronakos
    Pages 189-203
  15. David R. Powell, Phillip D. K. Lee, Adisak Suwanichkul
    Pages 205-214
  16. Matthew M. Rechler, Guck T. Ooi, Dae-shik Suh, Lucy Tseng
    Pages 227-236
  17. Cheryl A. Conover, Jay T. Clarkson, Susan K. Durham, Laurie K. Bale
    Pages 255-266
  18. Alwin G. P. Schuller, Johan W. van Neck, Dicky J. Lindenbergh-Kortleve, Cora Groffen, Ilona de Jong, Ellen C. Zwarthoff et al.
    Pages 267-277
  19. Naomi Hizuka, Kazue Takano, Kumiko Asakawa-Yasumoto, Izumi Fukuda, Tomoko Suzuki, Hiroshi Demura et al.
    Pages 301-309
  20. N. J. Rennert, S. D. Boulware, D. Kerr, S. Caprio, W. V. Tamborlane, R. S. Sherwin
    Pages 311-318
  21. J. R. Florini, D. Z. Ewton, K. A. Magri, F. J. Mangiacapra
    Pages 319-326
  22. Xin-Jun Liu, Nicholas Ling
    Pages 367-376
  23. Subburaman Mohan, David J. Baylink
    Pages 397-406
  24. Thomas L. McCarthy, Michael Centrella
    Pages 407-414
  25. Back Matter
    Pages 415-417

About this book


The study of the insulin-like growth factor (IGF) family has become an exciting area of investigation. Initially, this family consisted of ligands (insulin, IGF-I and IGF-m and receptors (the insulin receptor, the type I or IGF-I receptor and the type II or IGF-IYM-6-P receptor). Subsequently, it was discovered that six specific binding proteips (lGFBPs 1-6) playa major role in the actions of this growth factor family. In addition, there are now more potential receptors when one considers the possible roles of the insulin-receptor related receptor (IRR) and hybrid receptor dimers composed of insulin and IGF-I receptor (half-receptors). Another important aspect of this area of research is the realization that the IGFs are not only essential for normal growth and development but, in addition play an important role in the normal specialized function(s) of all tissues of the body, including the nervous system, skeleton, reproductive system, kidney, and the immune system, to name but a few. The development of recombi!tant human IGF-I for clinical testing has been a major breakthrough for investigators. Potential uses include wound healing, reversal of catabolic states, diabetes, bone remodeling, recovery from acute renal failure and many others. will determine both its use and its potential hazards.


Diabetes Immune System Insulin Nervous System development growth factor insulin-like reproductive system tissue

Editors and affiliations

  • Derek Le Roith
    • 1
  • Mohan K. Raizada
    • 2
  1. 1.National Institutes of HealthBethesdaUSA
  2. 2.University of FloridaGainesvilleUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6301-9
  • Online ISBN 978-1-4615-2988-0
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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