Chemistry and Biology of Pteridines and Folates

  • June E. Ayling
  • M. Gopal Nair
  • Charles M. Baugh

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 338)

Table of contents

  1. Front Matter
    Pages i-xxvi
  2. Chemistry

  3. Tetrahydrobiopterin Dependent Hydroxylases

    1. Steven W. Bailey, Scott R. Boerth, Shirley B. Dillard, June E. Ayling
      Pages 47-54
    2. R. G. H. Cotton, D. W. Howells, J. A. Saleeba, I. Dianzani, P. M. Smooker, I. G. Jennings
      Pages 55-57
    3. Per M. Knappskog, Hans G. Eiken, Aurora Martinez, Sigridur Olafsdottir, Jan Haavik, Torgeir Flatmark et al.
      Pages 59-62
    4. Shankar Balasubramanian, Robert T. Carr, Christopher J. Bender, Jack Peisach, Stephen J. Benkovic
      Pages 67-70
    5. Jan Haavik, Eckhard Bill, Marek Lengen, Aurora Martìnez, Torgeir Flatmark, Alfred X. Trautwein
      Pages 71-76
    6. Aurora Martínez, Chitrananda Abeygunawardana, Jan Haavik, Torgeir Flatmark, Albert S. Mildvan
      Pages 77-80
    7. Paul F. Fitzpatrick
      Pages 81-86
    8. Behjat Kosar-Hashemi, Hiroyasu Taguchi, Wilfred L. F. Armarego
      Pages 93-96
  4. Tetrahydrobiopterin Regenerating Enzymes

    1. Seymour Kaufman, Bruce A. Citron, Michael Davis, Sheldon Milstien
      Pages 97-102
    2. Hans-Christoph Curtius, Sandro Ghisla, Hiroyuki Hasegawa, Nenad Blau, Igor Rebrin
      Pages 107-110
    3. Igor Rebrin, Hans-Ch. Curtius, Sandro Ghisla, Falko H. Herrmann
      Pages 111-114
    4. Kottayil I. Varughese, Ying Su, Matthew M. Skinner, Nguyen-huu Xuong, David A. Matthews, John M. Whiteley
      Pages 123-126
    5. David Randles, Hiroyasu Taguchi, Wilfred L. F. Armarego
      Pages 127-130
    6. C. M. Hardy, H. Averdunk, B. Paal, R. G. H. Cotton, W. L. F. Armarego
      Pages 131-134
    7. Peter M. Smooker, David W. Howells, Irma Dianzani, Richard G. H. Cotton
      Pages 135-138
  5. Tetrahydrobiopterin Biosynthesis

    1. Robert A. Levine, J. Christopher States, Panagiotis Z. Anastasiadis, Donald M. Kuhn
      Pages 139-145
    2. Cornelia Schmid, Winfried Meining, Sevil Weinkauf, Luis Bachmann, Harald Ritz, Sabine Eberhardt et al.
      Pages 157-162
    3. Yasuko Sohta, Tomoko Ohta, Masahiro Masada
      Pages 163-166
    4. Markus Gütlich, Karin Schott, Thomas Werner, Adelbert Bacher, Irmgard Ziegler
      Pages 167-170
    5. Stephen I. Lentz, Kei Hirayama, Gregory Kapatos
      Pages 171-174
    6. Toshie Harada, Kazuyuki Hatakeyama, Hiroyuki Kagamiyama
      Pages 183-186
    7. Josef Maier, Karin Schott, Thomas Werner, Adelbert Bacher, Irmgard Ziegler
      Pages 195-198
  6. Tetrahydrobiopterin Regulation

    1. Ernst R. Werner, Gabriele Werner-Felmayer, Günter Weiss, Helmut Wachter
      Pages 203-209
    2. Gregory Kapatos, Kei Hirayama, Stephen I. Lentz, Min Zhu, Susan Stegenga
      Pages 217-222
    3. Masaaki Hoshiga, Kazuyuki Hatakeyama, Hiroyuki Kagamiyama
      Pages 223-226
    4. Panagiotis Z. Anastasiadis, J. Christopher States, Donald M. Kuhn, Robert A. Levine
      Pages 227-230
    5. Nobuo Nakanishi, Satoshi Onozawa, Akiyoshi Isono, Masayuki Hara, Hiroyuki Hasegawa, Shozo Yamada
      Pages 231-234
    6. Jack C. Waymire, June E. Ayling, Gale L. Craviso
      Pages 235-238
    7. Teruhiko Iino, Hiroe Watanabe, W. L. Gyure, Toshio Mazda, Hiroyoshi Mieno, Motoo Tsusué
      Pages 243-246

About this book


The pteridines in their multitude of forms fulfill many roles in nature ranging from pigments to cofactors for numerous redox and one-carbon transfer reactions. This extraordinary diversity of function is unified by the unique chemistry of the pteridine heterocycle. The International Symposium on the Chemistry and Biology of Pteridines and Folates is a forum for presenting recent and exciting advances in this expanding field. In of ideas results that has often stimulated bringing together various disciplines, a synergy fresh approaches to major problems. The Tenth International Symposium held at Orange Beach, Alabama, March 21-23, 1993, proved no exception by providing new insights into folate enzymology, tetrahydrobiopterin and molybdopterin biosynthesis and function, enzyme synthesis and regulation, along with novel synthetic strategies for producing compounds that will expedite further study. The many outstanding scientific contributions found in the following chapters, which represent the work presented at the Symposium, are a reflection of the significant advances made since the Ninth International Symposium held in Zurich in 1989. Since the 7th International Symposium in St. Andrews, Scotland, a tradition has evolved of honoring scientists who have made outstanding contributions to pteridine research with a Gowland Hopkins medal and lectureship. Sir Frederick Gowland Hopkins initiated the first investigation of what later proved to be pteridines in his studies of the yellow and white colors of butterflies.


Glutamat biology chemistry enzyme enzymes metabolism research synthesis

Editors and affiliations

  • June E. Ayling
    • 1
  • M. Gopal Nair
    • 2
  • Charles M. Baugh
    • 3
  1. 1.Dept of Pharmacology College of MedicineUniversily of South AlabamaMobileUSA
  2. 2.Dept. of Biochemistry College of MedicineUniversity of South AlabamaMobileUSA
  3. 3.College of MedicineUniversily of South AlabamaMobileUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6287-6
  • Online ISBN 978-1-4615-2960-6
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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