The Mammalian Cochlear Nuclei

Organization and Function

  • Miguel A. Merchán
  • José M. Juiz
  • Donald A. Godfrey
  • Enrico Mugnaini

Part of the NATO ASI series book series (NSSA, volume 239)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Cellular Basis for Signal Processing in the Mammalian Cochlear Nuclei

  3. Developmental Issues

  4. Primary Inputs

  5. Intrinsic Connections

  6. Descending Projections

    1. Front Matter
      Pages N7-N7
    2. Richard L. Saint Marie, E.-Michael Ostapoff, Christina G. Benson, D. Kent Morest, Steven J. Potashner
      Pages 121-131
  7. Neurotransmitters of the Cochlear Nucleus

    1. Front Matter
      Pages N9-N9
    2. José M. Juiz, Maria E. Rubio, Robert H. Helfert, Richard A. Altschuler
      Pages 167-177
    3. Robert J. Wenthold, Chyren Hunter, Ronald S. Petralia
      Pages 179-194
    4. Steven J. Potashner, Christina G. Benson, E.-Michael Ostapoff, Nancy Lindberg, D. Kent Morest
      Pages 195-210
    5. Richard A. Altschuler, José M. Juiz, Susan E. Shore, Sanford C. Bledsoe, Robert H. Helfert, Robert J. Wenthold
      Pages 211-224
    6. Donald M. Caspary, Peggy S. Palombi, Patricia M. Backoff, Robert H. Helfert, Paul G. Finlayson
      Pages 239-252
    7. Douglas E. Vetter, Costantino Cozzari, Boyd K. Hartman, Enrico Mugnaini
      Pages 279-290
  8. Projections and Response Properties of Cochlear Nucleus Neurons

    1. Front Matter
      Pages N11-N11
    2. Dolores E. López, Miguel A. Merchán, Victoria M. Bajo, Enrique Saldaña
      Pages 291-301
    3. Philip H. Smith, Philip X. Joris, Matthew I. Banks, Tom C. T. Yin
      Pages 349-360
    4. Paul B. Manis, John C. Scott, George A. Spirou
      Pages 361-371
  9. Computer Modelling of the Cochlear Nucleus

    1. Front Matter
      Pages N13-N13
    2. Ray Meddis, Michael J. Hewitt
      Pages 385-394
    3. Eric D. Young, Jason S. Rothman, Paul B. Manis
      Pages 395-410
  10. Appendix: Cochlear Nucleus Prostheses

    1. Front Matter
      Pages N15-N15
    2. John K. Niparko, David J. Anderson, Kensall D. Wise, Josef M. Miller
      Pages 421-430
  11. Special Contributions in Honour of R. Lorente de Nó

About this book


The presence of sophisticated auditory processing in mammals has permitted perhaps the most significant evolutionary development in humans: that of language. An understanding of the neural basis of hearing is thus a starting point for elucidating the mechanisms that are essential to human communication. The cochlear nucleus is the first region of the brain to receive input from the inner ear and is therefore the earliest stage in the central nervous system at which auditory signals are processed for distribution to higher centers. Clarifying its role in the central auditory pathway is crucial to our knowledge of how the brain deals with complex stimuli such as speech, and is also essential for understanding the central effects of peripheral sensorineural hearing loss caused by, for example, aging, ototoxic drugs, and noise. Ambitious new developments to assist people with total sensorineural deafness, including both cochlear and cochleus nuclear implants, require a detailed knowledge of the neural signals received by the brainstem and how these are processed. Recently, many new data have been obtained on the structure and function of the cochlear nucleus utilizing combinations of anatomical, physiological, pharmacological and molecular biological procedures. Approaches such as intracellular dye-filling of physiologically identified neurons, localization of classical neurotransmitters, peptides, receptors and special proteins, or gene expression have opened the door to novel morphofunctional correlations.


Nervous System brain brainstem central nervous system mammals neurons neurotransmitter receptor

Editors and affiliations

  • Miguel A. Merchán
    • 1
  • José M. Juiz
    • 2
  • Donald A. Godfrey
    • 3
  • Enrico Mugnaini
    • 4
  1. 1.University of SalamancaSalamancaSpain
  2. 2.University of AlicanteAlicanteSpain
  3. 3.Medical College of OhioToledoUSA
  4. 4.University of ConnecticutStorrsUSA

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