Advertisement

The Underlying Molecular, Cellular and Immunological Factors in Cancer and Aging

  • Stringner Sue Yang
  • Huber R. Warner

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 330)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Background

  3. Genetics and Epigenetics

    1. J. Carl Barrett, Lois A. Annab, P. Andrew Futreal
      Pages 27-43
    2. S. Michal Jazwinski, James B. Chen, Jiayan Sun
      Pages 45-53
    3. Robin S. Quartin, Arnold J. Levine
      Pages 55-65
    4. James M. Pipas, Kay Pogue-Geile, Gene G. Finley, Christine A. Cartwright, Arnold I. Meiesler
      Pages 67-75
  4. Influence of Physiological Changes in the Immune Constitutions in Aging and Cancer

    1. Marilyn L. Thoman, D. N. Ernst, M. V. Hobbs, W. O. Weigle
      Pages 93-106
  5. Molecular Biology of Age-Related Changes in Some Types of Cancer

    1. Breast Cancer

      1. Julia C. Emerson, Sydney E. Salmon, William Dalton, Daniel L. McGee, Jin-Ming Yang, Floyd H. Thompson et al.
        Pages 107-118
      2. Robert B. Dickson, Michael D. Johnson, Dorraya El-Ashry, Yenian Eric Shi, Mozeena Bano, Gerhard Zugmaier et al.
        Pages 119-141
      3. Mary Beth Martin, Miguel Saceda, Ralph K. Lindsey
        Pages 143-153
    2. Breast Cancer

      1. John T. Isaacs
        Pages 167-184
      2. Wallace L. McKeehan, Jinzhao Hou, Pamela Adams, Fen Wang, Guo-Chen Yan, Mikio Kan
        Pages 203-213
  6. Molecular Epidemiology and Treatment Modality in Patients of Different Ages with Leukemias

  7. Drug Resistance

    1. Ronald A. Fleming, Robert L. Capizzi
      Pages 271-286
    2. Charles S. Morrow, Kenneth Cowan
      Pages 287-305
  8. Summation and Synthesis

  9. Back Matter
    Pages 329-336

About this book

Introduction

Background Cancer is a variety of malignancies generally associated with aging. As the overall health technology and health care delivery improved with the advances made in medicine and science in the United States, the life expectancy of the population also increased. The average life expectancy in the U. S. A. has increased from 49 years at the end of 1900 to 75 years today in 1990 (1-3). The population of 65 years and older that constituted 25. 5 million or 11. 3% of the total U. S. population in 1980(4) has now increased to 31. 1 million or 12. 5% of the population according to the 1990(5) census. As cancer diagnosis and treatment have improved, cancer mortality among patients under 55 has been significantly reduced within recent years *1; however, cancer incidence under 55 is still increasing at about 0. 4% per year (as compared to 1. 0% for all ages or 0. 6% for < 65) according to the 1990 review of the 15 year trends in the Cancer Statistics Review 1973-1987, published by the Surveillance, Epidemiology, and End Results (SEER) Program of the National Cancer Institute (NCI). In contrast, both cancer incidence and mortality have been increasing among the population 65 and over*2 at a rate of 1. 4% and 1. 0% respectively per year between 1973-1987(6).

Keywords

Endoplasmatisches Reticulum aging cancer epidemiology mortality

Editors and affiliations

  • Stringner Sue Yang
    • 1
  • Huber R. Warner
    • 2
  1. 1.National Cancer InstituteBethesdaUSA
  2. 2.National Institute on AgingBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-2926-2
  • Copyright Information Springer Science+Business Media New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6270-8
  • Online ISBN 978-1-4615-2926-2
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology