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New Concepts in the Pathogenesis of NIDDM

  • Claes Göran Östenson
  • Suad Efendić
  • Mladen Vranic

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 334)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Regulation of Insulin Secretion

    1. Claes-Göran Östenson, Akhtar Khan, Suad Efendic
      Pages 1-11
    2. Per-Olof Berggren, Per Arkhammar, Md Shahidul Islam, Lisa Juntti-Berggren, Akhtar Khan, Henrik Kindmark et al.
      Pages 25-45
    3. Stephen J. H. Ashcroft, Ichiro Niki, Sue Kenna, Ling Weng, Jackie Skeer, Barbara Coles et al.
      Pages 47-61
  3. Insulin,Insulin Receptors and Glucose Transporters

    1. Pierre De Meyts
      Pages 89-100
    2. Holger Luthman, Ingrid Delin, Anna Glaser, Rolf Luft, Svante Norgren, Anna Wedell
      Pages 101-111
  4. Insulin Action in NIDDM

    1. Z. Q. Shi, A. Giacca, S. J. Fisher, M. Lekas, D. Bilinski, M. Van Delangeryt et al.
      Pages 151-168
    2. Ulf Smith, Stig Attvall, Jan Eriksson, Jesper Fowelin, Peter Lönnroth, Christian Wesslau
      Pages 169-180
    3. Richard N. Bergman, David C. Bradley, Marilyn Ader
      Pages 181-198
  5. Gluconeogenesis

    1. Alan D. Cherrington, Ralph W. Stevenson, Kurt E. Steiner, Cynthia C. Connolly, Masahiko Wada, Richard E. Goldstein
      Pages 199-208
    2. Bernard R. Landau
      Pages 209-220
    3. Jerry Radziuk, Susan Pye, Zi Zhang
      Pages 235-252
    4. John E. Gerich, Nurjahan Nurjhan
      Pages 253-258
  6. Gluconeogenesis

  7. Potential Impact of New Concepts in NIDDM on Delivery of Care to Diabetic Populations

    1. Phillip Gorden, Maureen I. Harris, Robert Silverman, Richard Eastman
      Pages 303-310
  8. Back Matter
    Pages 311-316

About this book

Introduction

The pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) has attracted the interest of our group during the last three decades. As early as 1969, a Nobel Symposium dealing with this topic was organized in Stockholm. This was followed in 1987 by a Nobel Conference devoted to the same subject. The main purpose of these meetings was to bring together the most distinguished scientists from all over the world and present theories on molecular and genetic mechanisms responsible for the development of glucose intolerance in NIDDM. This idea was followed also in the present symposium, "New Concepts in the Pathogenesis of NIDDM," organized with diabetologists from Toronto in Canada. Our purpose is to biannually organize international meetings covering important aspects of dia­ betes research, hoping that this type of interaction may result in new concepts and treat­ ment alternatives. For us, participating in this symposium in September 1992, the meeting in Stockholm was very stimulating and innovative. It is a special pleasure that almost all invited lecturers submitted manuscripts. Thus, the publication of the proceedings of the symposium makes it possible for all interested in diabetes research to share new ideas and findings presented at the meeting. Claes-G6ran Ostenson Suad Efendic Mladen V ranic v CONTENTS REGULATION OF INSULIN SECRETION Impaired Glucose-Induced Insulin Secretion: Studies in Animal Models with Spontaneous NIDDM . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . C. -G. Ostenson, A. Khan, and S. Efendic Perturbation ofIslet Metabolism and Insulin Release in NIDDM. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 WJ. Malaisse 2 Regulation of Cytoplasmic Free Ca+ in Insulin-Secreting Cells. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Keywords

Diabetes Diabetes mellitus Insulin Secretion Pathogene development insulin metabolism

Editors and affiliations

  • Claes Göran Östenson
    • 1
  • Suad Efendić
    • 1
  • Mladen Vranic
    • 2
  1. 1.Karolinska HospitalStockholmSweden
  2. 2.University of TorontoTorontoCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-2910-1
  • Copyright Information Plenum Press, New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6262-3
  • Online ISBN 978-1-4615-2910-1
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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