Mechanism of Myofilament Sliding in Muscle Contraction

  • Haruo Sugi
  • Gerald H. Pollack

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 332)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introductory Lecture on Muscle Contraction

  3. Structural Basis of Myofilament Sliding

    1. Front Matter
      Pages 11-11
    2. K. C. Holmes, M. Tirion, D. Popp, M. Lorenz, W. Kabsch, R. A. Milligan
      Pages 15-24
    3. Andrea Miegel, Lan Lee, Zbigniew Dauter, Yuichiro Maéda
      Pages 25-32
    4. M. K. Reedy, C. Lucaveche, M. C. Reedy, B. Somasundaram
      Pages 33-46
    5. Károly Trombitás, Gerald H. Pollack
      Pages 71-79
    6. A. R. Faruqi, R. A. Cross, J. Kendrick-Jones
      Pages 81-91
  4. Regulatory Mechanisms of Contraction

    1. Front Matter
      Pages 93-93
    2. C. C. Ashley, T. J. Lea, I. P. Mulligan, R. E. Palmer, S. J. Simnett
      Pages 97-115
    3. John Gergely, Zenon Grabarek, Terence Tao
      Pages 117-123
    4. Árvind Babu, Hong Su, Jagdish Gulati
      Pages 125-131
    5. Tien-tzu Hou, J. David Johnson, Jack A. Rail
      Pages 141-153
    6. Justin Molloy, Andrew Kreuz, Rehae Miller, Terese Tansey, David Maughan
      Pages 165-172
    7. J. C. Rüegg, J. D. Strauss, C. Zeugner, I. Trayer
      Pages 173-181
    8. Gabriele Pfitzert, Wolfgang Fischer, Joseph M. Chalovich
      Pages 195-203
  5. Biochemical Aspects of Actin-Myosin Interaction

  6. Properties of Actin-Myosin Sliding Studied by In Vitro Movement Assay Systems

  7. Properties of Actin-Myosin Sliding and Force Generation Studied by In Vitro Force-Movement Assay Systems

    1. Front Matter
      Pages 299-299
    2. Kazuhiko Kinosita Jr., Naoya Suzuki, Shin’ichi Ishiwata, Takayuki Nishizaka, Hiroyasu Itoh, Hiroyuki Hakozaki et al.
      Pages 321-329
    3. R. M. Simmonst, J. T. Finer, H. M. Warrick, B. Kralik, S. Chu, J. A. Spudich
      Pages 331-337
    4. Toshio Yanagida, Akihiko Ishijima, Kiwamu Saito, Yoshie Harada
      Pages 339-349
    5. S. Chaen, K. Oiwa, T. Kobayashi, T. Gross, E. Kamitsubo, T. Shimmen et al.
      Pages 351-360
    6. Toshio Ando, Naohiro Kobayashi, Eisuke Munekata
      Pages 361-376
  8. Structural Changes During Muscle Contraction Studied by X-Ray Diffraction

    1. Front Matter
      Pages 389-389
    2. H. Iwamoto, R. J. Podolsky
      Pages 393-407
    3. P. J. Griffiths, C. C. Ashley, M. A. Bagni, G. Cecchi, Y. Maèda
      Pages 409-422
    4. N. Yagi, S. Takemori, M. Watanabe
      Pages 423-433
    5. Katsuzo Wakabayashi, Hideaki Saito, Noriyoshi Moriwaki, Takakazu Kobayashi, Hidehiro Tanaka
      Pages 451-460
  9. Kinetic Properties of Actin-Myosin Sliding in Muscle Studied by Flash Photolysis of Caged Substances and Temperature Jump

    1. Front Matter
      Pages 471-471

About this book


This volume presents the entire proceedings of the symposium organized by one of us (H. S. ) on November 11 to 15, 1991 at Hakone, Japan, under the title of "Mechanism of Myofllament Sliding in Muscle Contraction. " Among various kinds of energy transduction mechanisms in biological systems, the mechanism of muscle contraction has been studied most intensively and extensively over many years. Since the monumental discovery by the two Huxleys and coworkers that muscle contraction results from relative sliding between the thick and thin myofilaments, attention of muscle investigators has been focused on the question, what makes the fllaments slide past one another. In response to the above question, A. F. Huxley and Simmons put forward a contraction model in 1971, in which globular heads of myosin (cross-bridges) extending from the thick fllament first attach to actin on the thin fllament, and then change their angle of attachment to actin (power stroke) leading to force generation or myofilament sliding until they detach from the thin fllament. The rocking cross-bridge contraction model seemed to be entirely consistent with the kinetic scheme of actomyosin ATPase published by Lymn and Taylor at the same time, thus giving a strong impression to the people concerned that the muscle contraction mechanism would soon be sorted out. In his review lecture in 1974, however, A. F.


ATP ATPase X-ray smooth muscle temperature

Editors and affiliations

  • Haruo Sugi
    • 1
  • Gerald H. Pollack
    • 2
  1. 1.Teikyo UniversityTokyoJapan
  2. 2.University of WashingtonSeattleUSA

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1993
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-6245-6
  • Online ISBN 978-1-4615-2872-2
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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