Brain Tumor Invasiveness

  • Ronald H. Goldfarb

Table of contents

  1. Front Matter
    Pages i-viii
  2. Unnur P. Thorgeirsson, Carol K. Lindsay, David W. Cottam, Daniel E. Gomez
    Pages 1-15
  3. Bruce W. Ennis, Lynn M. Matrisian
    Pages 17-21
  4. Yves A. De Clerck, Hiroyuki Shimada, Ignacio Gonzalez-Gomez, Corey Raffel
    Pages 23-33
  5. Jasti S. Rao, Peter A. Steck, Philip Tofilon, Douglas Boyd, Francis Ali-Osman, William G. Stetler-Stevenson et al.
    Pages 41-50
  6. Garth L. Nicolson, Motowo Nakajima, John L. Herrmann, David G. Menter, Philip G. Cavanaugh, June Sik Park et al.
    Pages 51-61
  7. Jerald J. Bernstein, William J. Goldberg, Edward R. Laws Jr.
    Pages 63-73

About this book


It is widely appreciated that the pathophysiology of advanced brain cancer is intimately related to the extent of tumor invasiveness. A prerequisite for comprehensively understanding neuro-oncology is therefore the elucidation of the biochemical and molecular properties of tumor cells that contribute to their invasiveness. An understanding of tumor invasion for central nervous system tumors is crucial since malignant brain tumors are very highly invasive and extensively destroy adjacent neural brain tissue. Moreover, they are angiogenesis-dependent and lead to the death of patients by expanding within the limited space of the cranium. As more specific insights are gained towards a full understanding of the complex process of tumor invasiveness of brain tumor cells, it should be possible to design strategies for the early diagnosis and treatment of invasive, advanced brain tumors. There is therefore an urgent need to better understand the cellular properties of brain tumor cells responsible for invasiveness.
This special issue of the JOURNAL OF NEURO-ONCOLOGY provides a state-of-the-art review of the general understanding of the process of tumor invasion. In addition, the articles emphasize specific aspects of aggressive brain cancers which are particularly important for deriving new insights for therapeutic approaches for advanced brain cancer that will target tumor invasiveness. The ideas discussed will stimulate further studies directed towards the translation of these important invasion-related studies to clinical approaches for the effective treatment of brain cancer.


Grading angiogenesis brain brain tumor brain tumors central nervous system melanoma metastasis nervous system pathophysiology tumor

Editors and affiliations

  • Ronald H. Goldfarb
    • 1
  1. 1.Pittsburgh Cancer InstituteUniversity of Pittsburgh Medical CenterUSA

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