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Alcohol, Cell Membranes, and Signal Transduction in Brain

  • Christer Alling
  • Ivan Diamond
  • Steven W. Leslie
  • Grace Y. Sun
  • W. Gibson Wood

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Lipid Structure, Domains and Proteins

    1. W. Gibson Wood, A. Muralikrishna Rao, Friedhelm Schroeder, Urule Igbavboa
      Pages 13-32
    2. Norman Salem Jr., Glenn Ward
      Pages 33-46
    3. Lena Gustavsson, Christofer Lundqvist, Elisabeth Hansson, F. David Rodríguez, Per Simonsson, Christer Alling
      Pages 63-73
    4. Christofer Lundqvist, Christer Larsson, Christer Alling, Lena Gustavsson
      Pages 75-82
  3. Receptors and Ion Channels

    1. Steven W. Leslie, Melanie S. Weaver
      Pages 97-106
    2. Forrest F. Weight, Robert W. Peoples, Jerry M. Wright, Chaoying Li, Luis G. Aguayo, David M. Lovinger et al.
      Pages 107-122
    3. Fulton T. Crews, Hunter Newsom, Mark Gerber, Colin Sumners, L. Judson Chandler, Gerhard Freund
      Pages 123-138
    4. Elias K. Michaelis, Mary L. Michaelis, Keshava N. Kumar
      Pages 139-149
    5. Molina C. Mhatre, Maharaj K. Ticku
      Pages 175-183
    6. V. Nachiappan, K. R. Shanmugasundaram, S. I. Mufti
      Pages 185-193
  4. Second Messenger Systems and Kinases

    1. Adrienne Gordon, Mohan K. Sapru, Sharon W. Krauss, Ivan Diamond
      Pages 195-203
    2. Jan B. Hoek, Tomoyuki Nomura, Katsuyoshi Higashi
      Pages 219-233
    3. Per Simonsson, F. David Rodríguez, Christer Larsson, Niklas Loman, Christer Alling
      Pages 235-244
    4. María del Carmen Boyano-Adánez, Lena Gustavsson
      Pages 265-272
    5. Shivendra D. Shukla, Cindy Y. Zhu, Ilsa I. Rovira, Archie W. Thurston Jr.
      Pages 273-282
  5. Gene Expression

    1. Michael F. Miles, Gregory Gayer, Michael Sganga
      Pages 283-298
    2. Fei Le, Peter Wilce, David Hume, Brian Shanley
      Pages 305-316
  6. Back Matter
    Pages 317-320

About this book

Introduction

Alcohol abuse and alcoholism are international problems whose costs economical­ ly, psychologically and medically have been well documented. Alcohol is a unique drug in that the effects of excessive use can have a deleterious effect on most if not all organs of the body. The brain is one of the organs most affected by excessive alcohol consumption. Effects on the brain can be seen in cognitive function, brain structure and neurochemistry. Over the past few years, there have been significant advances made in understanding how alcohol affects brain neurochemistry. This book examines four major areas, i. e. , membrane lipids, receptors and ion channels, second messengers, and gene expression, where significant advancements have been made. The book is divided into four sections based on the four major areas. In each section, data are examined that cover a range of approaches from in vitro to in vivo studies. The section on membrane lipids includes recent developments in how ethanol affects membrane cholesterol domains, polyunsaturated fatty acids, the cause and consequences of phosphatidylethanol formation, and the modulation of membrane protein function by lipid-protein interaction. The second section comprises chapters on NMDA and 5-HT3 receptors, including new aspects on alcohol neurotoxicity and the molecular heterogeneity that may underlie differences in alcohol sensitivity as well as chapters on GABA-gated chloride flux, and calcium channels.

Keywords

Calcium Lipid calcium channels gene expression genes molecular mechanisms signal transduction transcription

Editors and affiliations

  • Christer Alling
    • 1
  • Ivan Diamond
    • 2
  • Steven W. Leslie
    • 3
  • Grace Y. Sun
    • 4
  • W. Gibson Wood
    • 5
  1. 1.University of LundLundSweden
  2. 2.The Ernest Gallo Clinic and Research CenterUniversity of CaliforniaSan FranciscoUSA
  3. 3.The University of Texas at AustinAustinUSA
  4. 4.University of MissouriColumbiaUSA
  5. 5.Veterans Affairs Medical CenterUniversity of Minnesota School of MedicineMinneapolisUSA

Bibliographic information

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