© 1995

Cell Activation and Apoptosis in HIV Infection

Implications for Pathogenesis and Therapy

  • Jean-Marie Andrieu
  • Wei Lu

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 374)

Table of contents

  1. Front Matter
    Pages i-xi
  2. M. Peakman, M. Mahalingam, A. Pozniak, T. J. McManus, A. N. Phillips, D. Vergani
    Pages 17-26
  3. M. Stevenson, B. Brichacek, N. Heinzinger, S. Swindells, S. Pirruccello, E. Janoff et al.
    Pages 33-45
  4. Luis J. Montaner, Georges Herbein, Siamon Gordon
    Pages 47-56
  5. Jan van Lunzen, Jörn Schmitz, Kathrin Dengler, Claudia Kuhlmann, Herbert Schmitz, Manfred Dietrich
    Pages 57-70
  6. Jacques Corbeil, Douglas D. Richman
    Pages 91-99
  7. Naoki Oyaizu, Thomas W. Mc Closkey, Soe Than, Rong Hu, Savita Pahwa
    Pages 101-114
  8. Linde Meyaard, Frank Miedema
    Pages 115-120
  9. Seamus J. Martin, Douglas R. Green
    Pages 129-138
  10. Jean Claude Ameisen
    Pages 139-163
  11. Rémi Cheynier, Sven Henrichwark, Fabienne Hadida, Eric Pelletier, Eric Oksenhendler, Brigitte Autran et al.
    Pages 173-182
  12. J. D. Mountz, J. Cheng, X. Su, J. Wu, T. Zhou
    Pages 183-201
  13. Michael S. Ascher, Haynes W. Sheppard, John F. Krowka, Hans J. Bremermann
    Pages 203-210
  14. Ettaly Kara Franke, Jeremy Luban
    Pages 217-228

About this book


In the past decade, the global efforts in the control of HIV disease were basically concentrated on the search for anti-retroviral agents. So far, anti-HIV therapies have been shown to be disappointing because of rapid development of drug-resistant mutant variants. Despite this drawback in the therapeutic fight against HIV infection, antiviral research should be actively pursued. However, failure of antiviral therapy indicates that other avenues of research should be rapidly explored with the same energy. In this setting, striking advances have been recently made in the dissection and understanding of the viro-immunological processes governing the progressive destruction of lymphoid organs associated with AIDS develop­ ment, and HIV-induced activation and apoptosis have been identified as key phenomena of the immune system destruction. This book assembles the most recent advances on basic and clinical aspects ofT-cell activationiapoptosis in HIV infection and their implications for immunotherapy. These data were presented at an international symposium held on July 11-12, 1994, in Paris. The book is partitioned into 21 chapters covering four comprehensive fields: 1) T-celllmacrophage activation and HIV infection; 2) Apoptosis and viropathogenesis of HI V disease; 3) Apop­ tosis and immunopathogenesis ofHIV disease; 4) Mediators ofT-cell activationiapoptosis and therapeutic applications. We hope that this book will assist the readers in understanding recent advances in the viro-immunopathogenesis of HI V disease as well as the rationales for potential immune­ cell-targeted therapeutic interventions.


AIDS HIV HIV infection Pathogene development infection

Editors and affiliations

  • Jean-Marie Andrieu
    • 1
  • Wei Lu
    • 1
  1. 1.Laennec HospitalParisFrance

Bibliographic information

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