Hepatic Encephalopathy, Hyperammonemia, and Ammonia Toxicity

  • Vicente Felipo
  • Santiago Grisolia

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 368)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Kevin D. Mullen, Sigurbjorn Birgisson, Reynaldo C. Gacad, Hari Conjeevaram
    Pages 1-10
  3. Richard A. Hawkins, Anke M. Mans
    Pages 11-21
  4. R. A. F. M. Chamuleau, B. A. P. M. Vogels, D. K. Bosman, W. M. M. J. Bovée
    Pages 23-31
  5. Vicente Felipo, Elena Kosenko, María-Dolores Miñana, Goizane Marcaida, Santiago Grisolía
    Pages 65-77
  6. E. Anthony Jones, Cihan Yurdaydin, Anthony S. Basile
    Pages 89-101
  7. Peter Ferenci, Andreas Herneth, Andreas Püspök, Petra Steindl
    Pages 103-112
  8. José M. Mato, Luis Alvarez, Pablo Ortiz, Jesús Mingorance, Cristina Durán, María A. Pajares
    Pages 113-117
  9. Antoni Mas, Joan Manuel Salmerón, Joan Rodés
    Pages 119-123
  10. Richard A. Hawkins, John Jessy, Anke M. Mans, Antonio Chedid, Mary R. DeJoseph
    Pages 125-134
  11. Manal A. Morsy, C. Thomas Caskey
    Pages 145-154
  12. Jean-Christophe Pages, Marion Andreoletti, Myriam Bennoun, Dominique Franco, Pascale Briand, Anne Weber
    Pages 155-159
  13. Noris Siliprandi, R. Venerando, V. Tassani
    Pages 161-164
  14. Joaquín Berenguer, Martín Prieto, José Mir, Juan Cordoba, Miguel Rayón
    Pages 173-179
  15. Back Matter
    Pages 207-219

About this book


This volume contains the papers presented at the International Symposium on "Cirrhosis, Hyperammonemia and Hepatic Encephalopathy", held in Valencia, Spain, January 24th-27th, 1994. Liver cirrhosis and other hepatic dysfunctions such as fulminant hepatic failure and congenital defects of urea cycle enzymes can lead to hepatic encephalopathy, coma and death. Hepatic encephalopathy is one of the main causes of death in western countries. The ability to detoxify ammonia by its incorporation into urea is diminished by impaired liver function, resulting in increased ammonia levels in blood and brain. Hyperammonemia is considered one of the main factors in the mediation of hepatic encephalopathy and the classical clinical treatments are directed towards reducing blood ammonia levels. However, the molecular bases of the pathogenesis of hepatic encephalopathy and the role of hyperammonemia in this process remain unclear and several hypotheses have been proposed. To clarify the mechanisms involved in hepatic encephalopathy and hyperammonemia suitable animal models are necessary. The animal models available and the ideal features of an animal model are presented in the initial part of the book.


Pathogene brain death enzymes liver toxicity

Editors and affiliations

  • Vicente Felipo
    • 1
  • Santiago Grisolia
    • 1
  1. 1.Instituto de Investigaciones Citologicas de la F. I. B.ValenciaSpain

Bibliographic information

  • DOI
  • Copyright Information Plenum Press, New York 1994
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5820-6
  • Online ISBN 978-1-4615-1989-8
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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