• Nelson D. Horseman

Part of the Endocrine Updates book series (ENDO, volume 12)

Table of contents

  1. Front Matter
    Pages i-vii
  2. Karen A. Gregerson
    Pages 45-61
  3. Tom E. Porter, Mohamed E. El Halawani
    Pages 63-79
  4. Mark E. Molitch
    Pages 81-99
  5. Luis G. Sobrinho
    Pages 101-117
  6. Toni R. Prezant
    Pages 119-137
  7. Michael J. Soares, Daniel I. H. Linzer
    Pages 139-167
  8. Stuart Handwerger, Anoop Brar
    Pages 169-187
  9. Mary Y. Lorenson, Ameae M. Walker
    Pages 189-217
  10. Christopher J. Ormandy, Nelson D. Horseman, Matthew J. Naylor, Jessica Harris, Fiona Robertson, Nadine Binart et al.
    Pages 219-232
  11. J. Kindblom, K. Dillner, J. Törnell, H. Wennbo
    Pages 233-245
  12. Michael Risk, Geula Gibori
    Pages 265-295
  13. Elizabeth L. Hooghe-Peters, Zeynep Dogusan, Robert Hooghe
    Pages 317-339
  14. Marc Edery, Nadine Binart, Brigitte Bouchard, Vincent Goffin, Paul A. Kelly
    Pages 341-353
  15. Charles V. Clevenger, Michael A. Rycyzyn, Farhat Syed, J. Bradford Kline
    Pages 355-379
  16. Back Matter
    Pages 405-412

About this book


It is an authentic privilege to have the opportunity to assemble and edit a new volume on "Prolactin," the first in several decades to be devoted to this fascinating hormone in all its aspects. The obvious clinical rationale for understanding prolactin (PRL) is the frequent occurrence of prolactinomas, the most common type of pituitary tumor. Fortunately, medical management of prolactinomas can be based on our under­ standing of the physiology of hypothalamic control of the lactotroph. Armed with this knowledge, therapies for proiactinomas are highly successful and well tolerated. Be­ cause of the historical and practical importance of knowledge regarding the hypothala­ mus-Iactotroph axis, the first chapters of this volume are dedicated to reviewing the physiology, development, and cell biology of lactotroph regulation. Chapters focusing on prolactinomas and related clinical issues follow these. PRL is the primary hormone that is responsible for "parental care" in many verte­ brate species. This reproductive strategy is not unique to mammals, but it has devel­ oped through evolution to be the central distinguishing feature of the mammalian life cycle. Among the mammals, mice have become the most effective research species in recent years. This can be traced to the development of a wide range of methods for manipulating mouse genetics, and thereby influencing development, physiology and behavior. Mice also provide a profound illustration of the physiological challenges faced in maternity. Female mice undergo a post-partum estrous, and often are both pregnant and lactating simultaneously.


Pancreatic Islets apoptosis prolactin signal transduction signaling pathways transcription

Editors and affiliations

  • Nelson D. Horseman
    • 1
  1. 1.University of CincinnatiUSA

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2001
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5676-9
  • Online ISBN 978-1-4615-1683-5
  • Series Print ISSN 1566-0729
  • Buy this book on publisher's site
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