Frontiers in Modeling and Control of Breathing

1. Respiratory Neurons and Neural Networks

   1. Projections from Brainstem Gabaergic Neurons to the Phrenic Nucleus

      • Gang Song, Mamoru Aoki

      Pages 107-111

   2. Optical Recording of The Neuronal Activity in The Brainstem-Spinal Cord

      • Yasumasa Okada, Zibin Chen, Hideaki Yoshida, Shun-ichi Kuwana, Wuhan Jiang, Hirofumi Maruiwa

      Pages 113-118

   3. Interfacing Computer Models with Real Neurons: Respiratory “Cyberneurons” Created with the Dynamic Clamp

      • Christopher G. Wilson, Robert J. Butera Jr., Christopher A. Del Negro, John Rinzel, Jeffrey C. Smith

      Pages 119-124

2. Respiratory Rhythm and Pattern Generation

   1. Front Matter

      Pages 125-125

      PDF

   2. Is the Vertebrate Respiratory Central Pattern Generator Conserved?

      • M. S. Hedrick, L. Broch, M. Martinez, J. L. Powell, R. E. Wade

      Pages 127-132

   3. Unstable Breathing Rhythms and Quasiperiodicity in the Pre-Bötzinger Complex

      • Christopher A. Del Negro, Christopher G. Wilson, Robert J. Butera, Naohiro Koshiya, Sheree M. Johnson, Jeffrey C. Smith

      Pages 133-138

   4. Stationary Organotypic Culture of the Pre-Bötzinger Complex from the Newborn Rat

      • H. Rigatto, C. G. Wilson, N. Koshiya, S. House, J. C. Smith

      Pages 139-145

   5. Respiratory Rhythm Generation: Prebötzinger Neuron Discharge Patterns and Persistent Sodium Current

      • Donald R. McCrimmon, Armelle Monnier, Krzysztof Ptak, Greer Zummo, Zhong Zhang, George F. Alheid

      Pages 147-152

   6. Roles of the Bötzinger Complex in the Formation of Respiratory Rhythm

      • Gang Song, Qin Li, Ming Lü

      Pages 153-157

   7. Models of Neuronal Bursting Behavior: Implications for In-Vivo Versus In-Vitro Respiratory Rhythmogenesis

      • Ilya A. Rybak, Walter M. St John, Julian F. R. Paton

      Pages 159-164

   8. Neurogenesis of the Respiratory Pattern: Insights from Computational Modeling

      • Ilya A. Rybak, Julian F. R. Paton, James S. Schwaber

      Pages 165-170

   9. Reconfiguration of the Central Respiratory Network Under Normoxic and Hypdxic Conditions

      • Steven P. Lieske, Muriel Thoby-Brisson, Jan-Marino Ramirez

      Pages 171-178

   10. How is the Respiratory Central Pattern Generator Configured and Reconfigured?

       • Bruce G. Lindsey

       Pages 179-184

3. Development and Plasticity of Respiratory Control

   1. Front Matter

      Pages 185-185

      PDF

   2. Respiratory Suppression Induced by Nicotine Withdrawal in the Neonatal Rat Brainstem

      • Yasumasa Okada, Shun-ichi Kuwana, Masaki Iwanami

      Pages 187-194

   3. Effect of Dna Hypomethylation on Neural Control of Respiration: A Genetic Model

      • Guoping Fan, Marina Siniaia, Chi-Sang Poon, Rudolf Jaenisch

      Pages 195-200

   4. Respiratory Pattern and Hypdxic Ventilatory Response in Mice Functionally Lacking α2a-Adrenergic Receptors

      • John M. Bissonnette, Sharon J. Knopp, Danielle M. Wright, Leigh B. MacMillan

      Pages 201-208

   5. Do Genetic Factors Influence the Dejours Phenomenon?

      • Shyam Subramanian, Fang Han, Bernadette O. Erokwu, Thomas E. Dick, Kingman P. Strohl

      Pages 209-214

   6. Role of Nitric Oxide in Short-Term Potentiation and Long-Term Facilitation

      • David D. Kline, Nanduri R. Prabhakar

      Pages 215-219

   7. Induction of Long-Term Modulation of the Exercise Ventilatory Response in Man

      • James W. Reed, James C. Coates

      Pages 221-224

The field of neural control of breathing has advanced rapidly in the past two decades, with the emergence of many new and promising research directions of increasing sophistication. The complexity and diversity of the current methodologies signify its remarkable vivacity, albeit at the price of much confusion. Captured in this book are the broad and intricate nature of the field and its multifaceted frontiers, including aspects of genetics, cell and molecular biology, comparative biology, neurophysiology, neurochemistry, neuroanatomy, imaging, human physiology in health and disease, and influence of environmental factors. Major topics include chemosensitivity, respiratory sensation, respiratory neurons, rhythmogenesis, plasticity, development, chemoreflex and exercise, respiratory instability and variability with behavioral and sleep states, etc., which are systematically laid out in the book for easy referencing.

• Overholt
• Stent
• brainstem
• cells
• clonidine
• dopamine
• neurons
• neurophysiology
• physiology
• respiration

• Massachusetts Institute of Technology, Cambridge, USA

  Chi-Sang Poon

• Massachusetts General Hospital and Harvard Medical School, Boston, USA

  Homayoun Kazemi

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