Peroxisome Proliferator Activated Receptors: From Basic Science to Clinical Applications

  • J.-C. Fruchart
  • A. M. GottoJr.
  • R. Paoletti
  • B. Staels
  • A. L. Catapano

Part of the Medical Science Symposia Series book series (MSSS, volume 18)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Structure, Function, and Molecular Mechanisms of PPAR Action

    1. Timothy M. Willson, Millard H. Lambert, H. Eric Xu
      Pages 5-8
    2. Ajay Chawla, Chih-Hao Lee, Yaacov Barak, Debbie Liao, Ronald M. Evans
      Pages 9-16
  3. Inflammation and Atherosclerosis

    1. Antoine Pilon, Hélène Duez, Jean-Charles Fruchart, Bart Staels
      Pages 25-34
    2. Edward S. Horton, A. Enrique Caballero, Rola Saouaf, Aristidis Veves
      Pages 35-40
  4. PPARγ and α as Therapeutic Targets in Diabetes

    1. Hiroyuki Kimura, Junichi Sakamoto, Shinji Moriyama, Hiroyuki Odaka, Yu Momose, Yasuo Sugiyama et al.
      Pages 41-47
    2. Steven Kliewer
      Pages 49-53
  5. Animal Models to Study PPAR Functions

  6. PPARα: From Basic Science to Clinical Applications

    1. Jean-Charles Fruchart, Bart Staels, Patrick Duriez
      Pages 63-79
    2. Jorge Plutzky
      Pages 81-87
    3. Maria Febbraio, Antonio M. Gotto Jr., Jihong Han, Andrew C. Nicholson, Kavita Sharma, Eugene A. Podrez et al.
      Pages 89-94
  7. Lipid and Lipoprotein Metabolism and Atherosclerosis

    1. Philip Barter, Paul Baker, Jennifer Gamble, Mathew Vadas, Kerry-Anne Rye
      Pages 95-101
  8. The Importance of Raising HDL: From PPARα to Clinical Implications

    1. Guido Franceschini, Barbara Villa, Monica Gomaraschi, Laura Calabresi
      Pages 103-108
    2. Anders Hamsten, George Steiner, Diabetes Atherosclerosis Intervention Study Investigators
      Pages 109-114
  9. Adipose tissue, Obesity, and Diabetes

    1. Edward W. Kraegen, Gregory J. Cooney, Jiming Ye, Stuart M. Furler
      Pages 115-122
    2. Stephen R. Farmer, Jonathan K. Hamm, Bae-Hang Park
      Pages 123-130
  10. PPARδ Function and Biology

    1. William Oliver Jr., Dan Sternbach, Barbara Hansen, Timothy Willson
      Pages 131-134
  11. PPARγ: From Basic Science to Clinical Applications

  12. Clinical Studies with PPAR Ligands

    1. Anne Flanigan, Thomas A. Judge, James D. Lewis, Robert J. Stein, Gary R. Lichtenstein, Julius J. Deren et al.
      Pages 157-162
  13. Back Matter
    Pages 169-172

About this book


Peroxisome Proliferator Activated Receptors (PPARs) attract great attention in light of the wide spectrum of genes of biological and medical relevance identified as under their control. As a consequence, our knowledge of the role of these receptors in physiology and pathology continues to grow at a fast pace and PPARs have become an interesting target for the treatment of many pathological conditions, including diabetes and atherosclerosis. This volume provides an authoritative view of the current clinical and scientific developments within this evolving area of study.


Activation Lipid Macrophages Peroxisom inflammatory response influence metabolism molecular mechanisms pathophysiology physiology proteins regulation

Editors and affiliations

  • J.-C. Fruchart
    • 1
  • A. M. GottoJr.
    • 2
  • R. Paoletti
    • 3
  • B. Staels
    • 4
  • A. L. Catapano
    • 3
  1. 1.Faculté des Sciences Pharmaceutiques et Biologiques, Inserm U 545, Dept. AtheroscleroseInstitut Pasteur de Lille, Université de Lille IILilleFrance
  2. 2.Weill Medical College of Cornell UniversityNew YorkUSA
  3. 3.Department of Pharmacological SciencesUniversity of MilanMilanItaly
  4. 4.Department of Atherosclerosis, Pasteur Institute, Inserm U 545University of Lille IILilleFrance

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers and Fondazione Giovanni Lorenzini 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5427-7
  • Online ISBN 978-1-4615-1171-7
  • Series Print ISSN 0928-9550
  • Buy this book on publisher's site
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