Heme Oxygenase in Biology and Medicine

  • Nader G. Abraham

Table of contents

  1. Front Matter
    Pages i-xix
  2. Physiology/Pathology of Heme Oxygenase and its Products, Carbon Monoxide and Bilirubin

    1. Front Matter
      Pages 1-1
    2. Stefan W. Ryter, Leo E. Otterbein, Danielle Morse, Augustine M. K. Choi
      Pages 19-29
    3. Rui Wang, Xianfeng Sun, Lingyun Wu, Zunzhe Wang, Salma Toma Hanna, Robert Peterson-Wakeman
      Pages 31-41
    4. Toshisuke Morita, Yuko Togane, Makoto Suematsu, Jun-ichi Yamazaki, Shigehiro Katayama
      Pages 43-54
    5. Daniel S. Seidman, Micha Baum, Doron Kreiser, Israel Hendler, Eyal Schiff, Maurice Druzin et al.
      Pages 55-65
    6. Peter Hewett, Asif Ahmed
      Pages 67-82
    7. Mutsuo Yamaya, Shoji Okinaga, Kiyohisa Sekizawa, Mizue Monma, Hidetada Sasaki
      Pages 83-95
    8. Józef Dulak, Roberto Motterlini, Ihor Huk, Otmar Pachinger, Franz Weidinger, Alicja Józkowicz
      Pages 97-107
  3. Physiological Function of Heme Oxygenase and the Central Nervous System

    1. Front Matter
      Pages 109-109
    2. Charles W. Leffler, Jonathan H. Jaggar, Zheng Fan
      Pages 111-119
    3. G. Scapagnini, A. M. Giuffrida Stella, N. G. Abraham, D. Alkon, V. Calabrese
      Pages 121-134
    4. Atsushi Takeda, Yasuto Itoyama, Teiko Kimpara, R. Krishnan Kutty, Nader G. Abraham, Barney E. Dwyer et al.
      Pages 135-143
    5. Yogesh Mawal, Daniel Berlin, Steven Kravitz, Hyman M. Schipper
      Pages 145-155
    6. Martin H. Deininger, Richard Meyermann, Hermann J. Schluesener
      Pages 169-180
  4. Clinical Implications of Heme Oxygenase System in Inflammation

    1. Front Matter
      Pages 181-181
    2. Michael W. Dunn, Michal Laniado-Schwartzman
      Pages 183-192
    3. Stella Kourembanas, Tohru Minamino, Helen Christou, Chung-Ming Hsieh, Yuxiang Liu, Vijender Dhawan et al.
      Pages 193-204
    4. Camille Taillé, Roberta Foresti, Colin Green, Michel Aubier, Roberto Motterlini, Jorge Boczkowski
      Pages 205-213
    5. P. O. Berberat, L. Günther, S. Brouard, M. P. Soares, F. H. Bach
      Pages 215-226
  5. Heme Oxygenase and Cardiovascular System

    1. Front Matter
      Pages 239-239
    2. Prasun K. Datta, Elias A. Lianos
      Pages 251-258
    3. Tobias Polte, Anke Hemmerle, Nina Grosser, Aida Abate, Henning Schröder
      Pages 259-268
    4. Jesus Araujo, Kazunobu Ishikawa, Aldons J. Lusis
      Pages 269-278
    5. Germán Camejo, Ana Z. Fernandez, Flor López, Alfonso Tablante, Egidio Romano, Eva Hurt-Camejo et al.
      Pages 279-292
    6. Kazunobu Ishikawa
      Pages 293-301
    7. Amel F. Khelifi, Vivien E. Prise, Roberta Foresti, James E. Clark, Chryso Kanthou, Roberto Motterlini et al.
      Pages 303-312
  6. Heme Oxygenase System and Oxidative Stress Response

    1. Front Matter
      Pages 323-323
    2. A. Yachie, T. Toma, S. Shimura, L. Yue, K. Morimoto, K. Maruhashi et al.
      Pages 325-334
    3. Maria Alfonsina Desiderio, Lorenza Tacchini
      Pages 335-341
    4. Gerben J. Schaaf, Roel F. M. Maas, Els M. de Groene, Johanna Fink-Gremmels
      Pages 353-363
    5. Daniel Stewart, Julia L. Cook, Jawed Alam
      Pages 377-386
    6. Toru Takahashi, Reiko Akagi, Hiroko Shimizu, Masahisa Hirakawa, Shigeru Sassa
      Pages 387-397
    7. Jian-Xiong Chen, Heng Zeng, Xiu Chen, Ching-Yuan Su, Chen-Ching Lai
      Pages 399-408
    8. Florence Favatier, Barbara S. Polla
      Pages 409-421
    9. Alfredo Vannacci, Cosimo Marzocca, Giovanni Zagli, Simone Pierpaoli, Daniele Bani, Emanuela Masini et al.
      Pages 431-435
  7. The Network of Heme Oxygenase and Program Cell Growth and Death

    1. Front Matter
      Pages 437-437
    2. Xiao-Ming Liu, Kelly J. Peyton, William Durante
      Pages 439-447
    3. Alvin I. Goodman, Giovanni Li Volti, Nader G. Abraham, Lucia Malaguarnera
      Pages 459-467
    4. Elba Vázquez, Esther Gerez, Fabiana Caballero, Leda Oliveri, Nora Falcoff, María Lujan Tomaro et al.
      Pages 469-479

About this book


Heme oxygenase is rapidly taking its place as the centerpiece of multiple inter­ acting metabolic systems. Only 25 years ago heme oxygenase and its metabolic prod­ ucts appeared to be merely a simple metabolic system-one substrate, heme; one enzyme, heme oxygenase; and one set of products, iron to be recycled, and bilirubin and carbon monoxide to be disposed. From a group of about 25 people in 1974, as judged by attendance at various Gordon conferences, heme oxygenase has, in the year 2000, attracted working scientists-and clinicians I might add-by the hundreds and has produced referenced publications by the thousands. It is well-deserved attention. Heme oxygenase system is now similar to the metabolic networks surrounding glucose in those complex maps of glycolytic and non-glycolytic metabolic pathways, which we had to memorize as students. The relevance of heme oxygenase to regulatory biology was recognized many years ago, but the work conducted over the past five years has created a new wave of emphasis focusing on genetic manipulation to alter heme oxygenase gene expression, the regulatory actions of heme oxygenase products including carbon monoxide, and the significance of changes in the heme oxygenase system. The physiological and pathological relevance of heme oxygenase in the brain, heart, liver, bone marrow, organ transplant, lung and kidney, opens many areas of investigation in various dis­ ciplines. Advances in the pharmacology of bilirubin and its ability as an antioxidant have provided a new avenue in clinical research.


DNA genes genetics molecular biology molecular mechanisms translation

Editors and affiliations

  • Nader G. Abraham
    • 1
  1. 1.New York Medical CollegeValhallaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2002
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5219-8
  • Online ISBN 978-1-4615-0741-3
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology