PAS Proteins: Regulators and Sensors of Development and Physiology

  • Stephen T. Crews

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Zhong Xuejun, Hao Bing, Michael K. Chan
    Pages 1-16
  3. Barry L. Taylor, Mark S. Johnson, Kylie J. Watts
    Pages 17-50
  4. Jo Anne Powell-Coffman
    Pages 51-68
  5. Yao Guang, Eric B. Harstad, Christopher A. Bradfield
    Pages 149-182
  6. John B. Hogenesch, Steve A. Kay
    Pages 231-252
  7. Back Matter
    Pages 253-263

About this book


PAS proteins control numerous physiological and developmental events, and span phylogeny from bacteria to man. Bacterial and plant PAS proteins act as sensors of environmental stimuli, including light, oxygen, and energy status.

Not surprising, given these roles, there is intense investigation of the roles of bHLH-PAS proteins in issues of human health including: (1) cancer induction, (2) cancer growth and vascularity, (3) birth defects, including Down syndrome, (4) appetite control and obesity, (5) sleep rhythm disorders, and (6) mental health disorders such as social interactions and learning.

PAS proteins encompass many fields of biology, and scientists who work in these fields (circadian rhythms, oxygen regulation, toxin metabolism, bacterial sensors, and development) are an audience, particularly those who actively work on PAS proteins and researchers interested in transcriptional control, signal transduction, and evolution.


Evolution biochemistry genes metabolism proteins signal transduction transcription

Editors and affiliations

  • Stephen T. Crews
    • 1
  1. 1.The University of North Carolina at Chapel HillChapel HillUSA

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