The Physiological Genomics of the Critically Ill Mouse

  • Can Ince

Part of the Basic Science for the Cardiologist book series (BASC, volume 16)

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Physiological Monitoring of the Mouse

    1. Front Matter
      Pages 1-1
    2. Edwin Spoelstra, René Remie
      Pages 11-21
    3. Coert J. Zuurbier, Vanessa M. Emons, Anneke Koeman, Can Ince
      Pages 23-34
    4. Lothar A. Schwarte, Can Ince
      Pages 35-51
    5. Attila Kovacs, Michael Courtois
      Pages 53-71
    6. Egbert G. Mik, Can Ince
      Pages 73-88
    7. Ivo Amende, J. Matthew Dubach, Katrina Piskorski, James P. Morgan, Thomas G. Hampton
      Pages 89-100
    8. Klaas Nicolay, Gustav J. Strijkers, Jeanine J. Prompers, Maarten R. Drost
      Pages 101-117
    9. Adriaan A. Lammertsma
      Pages 119-126
    10. Klaas Kramer, Steve Hachtman
      Pages 127-141
  3. Cardiovascular Pathophysiology of the Mouse

    1. Front Matter
      Pages 143-143
    2. Thorsten Vowinkel, D. Neil Granger
      Pages 145-158
    3. Steven M. Hollenberg
      Pages 159-177
    4. Alina Constantinescu, Hans Vink
      Pages 179-186
    5. Martin G. Schwacha, Irshad H. Chaudry
      Pages 187-200
    6. Petra E. M. H. Habets, Antoon F. M. Moorman, Vincent M. Christoffels
      Pages 201-210
    7. Ben Janssen, Tijl De Celle, Jos Paquay, Jos Smits, Matthijs Blankesteijn
      Pages 211-224
    8. Gerd Albuszies
      Pages 225-238
    9. Marcus J. Schultz, Tom van der Poll
      Pages 275-288
  4. Treating the Critically Ill Mouse

    1. Front Matter
      Pages 289-289
    2. Dirk J. Duncker, Rien van Haperen, Elza van Deel, Monique de Waard, Barend Mees, Rini de Crom
      Pages 291-310
    3. Imo E. Hoefer, Michiel Voskuil, Niels van Royen
      Pages 311-327
    4. Lieve Moons, Aernout Luttun, Peter Carmeliet, Ed Conway
      Pages 329-347
    5. Douwe E. Atsma
      Pages 349-361
    6. Philip A. Efron, Lyle L. Moldawer
      Pages 363-381
  5. Back Matter
    Pages 383-386

About this book


The physiological genomics of the cardiovascular system studies the relationship between gene and physiological (dys)function. It is a rapidly developing area of research and distinguishes itself from other areas of molecular medicine by its highly integrative nature. In this multi­ disciplinarian area of the physiological sciences, there is interaction between gene structure and physiological cardiovascular function as well as interactions between the different organs and their physiological compartments. The mouse has played a central role in the study of genomics due to the detailed knowledge of the mouse genome and the wide availability of genetically modified mice. In the past, the mouse had mainly been used in the area of immunology and molecular biology, and physiological interest in the mouse was scarce. As more insight has come into the structural genomics of the mouse, however, it has become increasingly important to understand the relation between gene and physiological function. With this in mind we have been organizing the Amsterdam Mouse Symposia to bring together different disciplines interested in the molecular basis of cardiovascular function (see J. of Clinical and Exp. Pharmacology and rd Physiology (2002) 29:A69-AI02 for the proceedings of the 3 Amsterdam Mouse Symposium and Basic Research in Cardiology (2000) 95:492-535 for nd the proceedings of the 2 symposium).


anesthesia animals cardiovascular cardiovascular system cell echocardiography electrocardiogram (ECG) gene therapy genes genomics heart hemodynamics physiology vascular disease

Editors and affiliations

  • Can Ince
    • 1
  1. 1.Department of Physiology Academic Medical CenterUniversity of AmsterdamThe Netherlands

Bibliographic information

  • DOI
  • Copyright Information Kluwer Academic Publishers 2004
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-5099-6
  • Online ISBN 978-1-4615-0483-2
  • Series Print ISSN 1566-0753
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology