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Novel Angiogenic Mechanisms

Role of Circulating Progenitor Endothelial Cells

  • Nicanor I. Moldovan

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 522)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Domenico Ribatti, Angelo Vacca, Beatrice Nico, Enrico Crivellato, Giuseppe De Falco, Marco Presta
    Pages 25-36
  3. Maria B. Grant, Sergio Caballero, Gary A. J. Brown, Steven M. Guthrie, Robert N. Mames, Timothy Vaught et al.
    Pages 37-45
  4. Klaus Havemann, Beatriz F. Pujol, Jürgen Adamkiewicz
    Pages 47-57
  5. Alexander Schmeisser, Christiane Graffy, Werner G. Daniel, Ruth H. Strasser
    Pages 59-74
  6. Matthias Clauss, Frederic Pipp, Katja Issbrücker, Herbert Weich, Matthias Heil, Wolfgang Schaper
    Pages 75-82
  7. Patrizia Mancuso, Angelica Calleri, Cristina Cassi, Alberto Gobbi, Manuela Capillo, Giancarlo Pruneri et al.
    Pages 83-97
  8. Back Matter
    Pages 115-120

About this book

Introduction

New experimental observations often require fresh concepts for their interpretation, and at times even changes of paradigms. This is the situation with the recent realization that circulating endothelial progenitor cells may have an important contribution to the maintenance and formation of new endothelium in adult organisms, in a surprisingly wide variety of situations. The classical paradigm of angiogenesis, centered on the notion of "sprouting" can hardly accommodate them. It was previously realized that it needs to be "stretched out" to include alternative mechanisms of microvascular development, such as intussusception and capillary fusion. However, a major debate where to reconsider the sprouting mechanism, and to promote alternative views, did not take place yet. The number of publications in this field increased exponentially in the last years. Nevertheless, the concepts and notions so much needed to describe and to explain the new observations are still scarce, and heterogeneous. Within the larger community dedicated to the study of angiogenesis, the researchers involved in investigation of circulating precursor endothelial cells biology represent a subgroup with specific preoccupations and opinions. Many of them did not meet each other so far, and no major scientific events have been dedicated before exclusively to their interests. For the above reasons, the idea to organize a symposium addressing the new developments in angiogenesis research was received with enthusiasm by all those involved in its preparation.

Keywords

angiogenesis cardiovascular cells endothelium tissue

Editors and affiliations

  • Nicanor I. Moldovan
    • 1
  1. 1.The Ohio State UniversityColumbusUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4615-0169-5
  • Copyright Information Kluwer Academic/Plenum Publishers 2003
  • Publisher Name Springer, Boston, MA
  • eBook Packages Springer Book Archive
  • Print ISBN 978-1-4613-4951-8
  • Online ISBN 978-1-4615-0169-5
  • Series Print ISSN 0065-2598
  • Buy this book on publisher's site
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