Hypoxia and Cancer

Biological Implications and Therapeutic Opportunities

  • Giovanni Melillo

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Biology

    1. Front Matter
      Pages 1-1
    2. Luana Schito, Gregg L. Semenza
      Pages 3-19
    3. Monica M. Olcina, Ester M. Hammond
      Pages 21-41
    4. Mircea Ivan, Xiaoling Zhong, Simona Greco, Fabio Martelli
      Pages 43-64
    5. Agnes Görlach
      Pages 65-90
    6. Maria Carla Bosco, Luigi Varesio
      Pages 91-119
    7. Silvia Pastorekova, Claudiu T. Supuran
      Pages 121-153
  3. Imaging

    1. Front Matter
      Pages 155-155
    2. Mary-Keara Boss, Gregory M. Palmer, Mark W. Dewhirst
      Pages 157-178
    3. Michael R. Horsman, Morten Busk, Thomas Nielsen, Marianne Nordsmark, Jens Overgaard
      Pages 179-201
  4. Therapy

    1. Front Matter
      Pages 203-203
    2. Dietmar W. Siemann, Yao Dai, Michael R. Horsman
      Pages 205-227
    3. Carly M. Sayers, Souvik Dey, Stacey L. Lehman, Constantinos Koumenis
      Pages 229-251
    4. Raymond J. Louie, Mercè Padró, Amato J. Giaccia, Denise A. Chan
      Pages 253-264
    5. Marianne Nordsmark, Jan Alsner, Morten Busk, Jens Overgaard, Michael R. Horsman
      Pages 265-281
    6. William R. Wilson, Kevin O. Hicks, Jingli Wang, Frederik B. Pruijn
      Pages 283-328
    7. Nicole D. Fer, Annamaria Rapisarda
      Pages 329-341
    8. Geoff S Higgins, Adrian L Harris
      Pages 343-359
  5. Back Matter
    Pages 361-363

About this book


The tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for  understanding how hypoxia impacts the biology, imaging and therapy of human cancers.  Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy.


cancer microenvironment tumor hypoxia

Editors and affiliations

  • Giovanni Melillo
    • 1
  1. 1.Bristol-Myers SquibbPrincetonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-9166-8
  • Online ISBN 978-1-4614-9167-5
  • Series Print ISSN 2196-9906
  • Series Online ISSN 2196-9914
  • Buy this book on publisher's site
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Oncology & Hematology
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