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© 2014

Drug Delivery to the Brain

Physiological Concepts, Methodologies and Approaches

  • Margareta Hammarlund-Udenaes
  • Elizabeth C.M. de Lange
  • Robert G. Thorne

Benefits

  • Describes small and large drug delivery to the brain with emphasis on the physiology and concepts for drug delivery across the BBB and brain distribution

  • Contains methods for studying drug delivery, routes, and approaches of drug administration and drug industry perspectives

  • Cutting-edge and at the same time educational, so that the book can be used in high-level training of academic and industry scientists

Book

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 10)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Physiology and Basic Principles for Drug Handling by the Brain

    1. Front Matter
      Pages 1-1
    2. Xavier Declèves, Nathalie Strazielle, Jean-Michel Scherrmann, Jean-François Ghersi-Egea
      Pages 101-124
  3. Pharmacokinetic Concepts and Methods for Studying Drug Delivery

    1. Front Matter
      Pages 125-125
    2. Margareta Hammarlund-Udenaes
      Pages 127-161
    3. N. Joan Abbott, Diana E. M. Dolman, Siti R. Yusof, Andreas Reichel
      Pages 163-197
    4. Quentin R. Smith, Ramakrishna Samala
      Pages 199-211
  4. Industrial Approaches for Investigation of Potential Central Nervous System Drugs

  5. Strategies for Improved Central Nervous System Drug Delivery

    1. Front Matter
      Pages 399-399
    2. Jeffrey J. Lochhead, Robert G. Thorne
      Pages 401-431
    3. Pieter J. Gaillard, Corine C. Visser, Marco de Boer, Chantal C. M. Appeldoorn, Jaap Rip
      Pages 433-454

About this book

Introduction

This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain. The book also explores different approaches for predicting human brain concentrations as well as the influence of disease and drug industry perspectives. In addition to wide-ranging coverage of physiological concepts relevant to central nervous system (CNS) drug delivery, a detailed review of brain structure, function, blood supply and fluids is also provided. In each chapter, descriptions of future challenges and unresolved questions are combined with points for discussion. This unique combination of material makes this book a valuable resource for students and for established academic and industry scientists looking to learn about state-of-the-art drug delivery research. It is also a source for stimulating new ideas among experts already performing CNS drug delivery research or working in related areas.

 

Margareta Hammarlund-Udenaes (Ph.D.) is a Professor in Pharmacokinetics and Pharmacodynamics (PK/PD) at Uppsala University and the Head of the Translational PK/PD Group. Her research is focused on studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, and it has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug relationships.

 

Elizabeth C.M. de Lange (Ph.D.) is Head of the Target Site Equilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR).  Her research program focuses on the development of generally applicable predictive PK/PD models on CNS drugs using advanced in vivo animal models and mathematical modeling techniques, with a number of recent successes.

 

Robert G. Thorne (Ph.D.) is an Assistant Professor in Pharmaceutical Sciences at the University of Wisconsin-Madison School of Pharmacy. He was previously a research scientist and faculty member in the Department of Physiology & Neuroscience at the New York University School of Medicine. His research focuses on diffusive and convective transport within the CNS and the development, refinement and optimization of strategies for delivering biologics into the brain.

Keywords

blood-brain barrier drug delivery blood-brain barrier transporters

Editors and affiliations

  • Margareta Hammarlund-Udenaes
    • 1
  • Elizabeth C.M. de Lange
    • 2
  • Robert G. Thorne
    • 3
  1. 1.Pharmaceutical BiosciencesUppsala University Pharmacokinetics and Drug TherapyUppsalaSweden
  2. 2.LACDR/PharmacologyLeiden UniversityLeidenThe Netherlands
  3. 3.Pharmaceutical Sciences DivisionUniversity of Wisconsin-Madison School of PharmacyMadisonUSA

About the editors

Margareta Hammarlund-Udenaes (PhD) is a Professor in Pharmacokinetics and Pharmacodynamics (PKPD) at Uppsala University and the Head of the Translational PKPD Group. Her research is focused at studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, which has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug relationships. Dr. Hammarlund-Udenaes is an Associate Editor of Pharmaceutical Research and a member of the Editorial Advisory Board of Journal of Pharmaceutical Sciences and Fluids and Barriers of the CNS. She became an American Association of Pharmaceutical Scientists’ Fellow in 2005. She is a frequent lecturer at conferences and in drug industry. Her company gives courses and advice in PKPD and BBB transport issues. She co-founded and has co-chaired several of the International Symposia on Microdialysis, and she is the Chair of the ‘Barriers of the CNS’ Gordon Conference in 2014.

Elizabeth C.M. de Lange (PhD) is Head of the Target Site Equilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR). Her research program focuses on the development of generally applicable predictive PKPD models on CNS drugs using advanced in vivo animal models and mathematical modeling techniques, with a number of recent successes. She is an Editorial Board member of the journal Fluids and Barriers of the CNS, and an Editorial Advisory Board member of the Journal of Pharmaceutical Sciences and of Pharmaceutical Research. She has been the cofounder and (co-)Chair at the 1st, 2nd and 5th International Symposia on Microdialysis, and has been the Chair of the 9th International Conference on Cerebral Vascular Biology (2011). Among many other functions within the American Association of Pharmaceutical Scientists, she is the 2014 Chair of the Annual Meeting Programming Committee. With her company “In Focus” (www.infocus-ecmdelange.nl) she provides courses, training and advice on microdialysis, pharmacokinetics, BBB transport, intra-brain distribution and PKPD relationships.

Robert G. Thorne (PhD) is an Assistant Professor in Pharmaceutical Sciences at the University of Wisconsin-Madison School of Pharmacy and also serves as a Trainer in the Neuroscience, Cellular & Molecular Pathology, and Clinical Neuroengineering Training Programs at the University of Wisconsin-Madison. Dr. Thorne was previously a research scientist and Faculty member in the Department of Physiology & Neuroscience at the New York University School of Medicine. His background includes a Ph.D. in Pharmaceutics (University of Minnesota) and a B.S. in chemical engineering (University of Washington). His research focuses on diffusive and convective transport within the CNS and the development, refinement and optimization of strategies for delivering biologics into the brain. He is a frequent invited speaker on topics related to CNS drug delivery for organizations within academia, foundations, and the biotechnology and pharmaceutical industry. Dr. Thorne is a founder and Council / Steering Committee member of the International Brain Barriers Society (http://www.ibbsoc.org/) as well as the 2016 Chair-elect for the ‘Barriers of the CNS’ Gordon Research Conference. 

Bibliographic information

  • Book Title Drug Delivery to the Brain
  • Book Subtitle Physiological Concepts, Methodologies and Approaches
  • Editors Margareta Hammarlund-Udenaes
    Elizabeth C.M. de Lange
    Robert G. Thorne
  • Series Title AAPS Advances in the Pharmaceutical Sciences Series
  • Series Abbreviated Title AAPS Adv. Pharmaceutical Sciences
  • DOI https://doi.org/10.1007/978-1-4614-9105-7
  • Copyright Information American Association of Pharmaceutical Scientists 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences Biomedical and Life Sciences (R0)
  • Hardcover ISBN 978-1-4614-9104-0
  • Softcover ISBN 978-1-4939-4366-1
  • eBook ISBN 978-1-4614-9105-7
  • Series ISSN 2210-7371
  • Series E-ISSN 2210-738X
  • Edition Number 1
  • Number of Pages XX, 731
  • Number of Illustrations 24 b/w illustrations, 126 illustrations in colour
  • Topics Pharmaceutical Sciences/Technology
    Biomedicine, general
  • Buy this book on publisher's site
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