Drug Delivery to the Brain

Physiological Concepts, Methodologies and Approaches

  • Margareta Hammarlund-Udenaes
  • Elizabeth C.M. de Lange
  • Robert G. Thorne

Part of the AAPS Advances in the Pharmaceutical Sciences Series book series (AAPS, volume 10)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Physiology and Basic Principles for Drug Handling by the Brain

    1. Front Matter
      Pages 1-1
    2. Xavier Declèves, Nathalie Strazielle, Jean-Michel Scherrmann, Jean-François Ghersi-Egea
      Pages 101-124
  3. Pharmacokinetic Concepts and Methods for Studying Drug Delivery

    1. Front Matter
      Pages 125-125
    2. Margareta Hammarlund-Udenaes
      Pages 127-161
    3. N. Joan Abbott, Diana E. M. Dolman, Siti R. Yusof, Andreas Reichel
      Pages 163-197
    4. Quentin R. Smith, Ramakrishna Samala
      Pages 199-211
  4. Industrial Approaches for Investigation of Potential Central Nervous System Drugs

  5. Strategies for Improved Central Nervous System Drug Delivery

    1. Front Matter
      Pages 399-399
    2. Jeffrey J. Lochhead, Robert G. Thorne
      Pages 401-431
    3. Pieter J. Gaillard, Corine C. Visser, Marco de Boer, Chantal C. M. Appeldoorn, Jaap Rip
      Pages 433-454
    4. Adam K. Bevan, Brian K. Kaspar
      Pages 485-499
  6. Brain Drug Delivery in Disease Conditions

    1. Front Matter
      Pages 571-571
    2. Geert J. Schenk, Gijs Kooij, Arie Reijerkerk, Helga de Vries
      Pages 573-589
    3. Richard F. Keep, Jianming Xiang, Ningna Zhou, Anuska V. Andjelkovic
      Pages 635-656
  7. Back Matter
    Pages 683-731

About this book


This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB. It contains cutting-edge methods for studying drug delivery and administering drugs into the brain. The book also explores different approaches for predicting human brain concentrations as well as the influence of disease and drug industry perspectives. In addition to wide-ranging coverage of physiological concepts relevant to central nervous system (CNS) drug delivery, a detailed review of brain structure, function, blood supply and fluids is also provided. In each chapter, descriptions of future challenges and unresolved questions are combined with points for discussion. This unique combination of material makes this book a valuable resource for students and for established academic and industry scientists looking to learn about state-of-the-art drug delivery research. It is also a source for stimulating new ideas among experts already performing CNS drug delivery research or working in related areas.


Margareta Hammarlund-Udenaes (Ph.D.) is a Professor in Pharmacokinetics and Pharmacodynamics (PK/PD) at Uppsala University and the Head of the Translational PK/PD Group. Her research is focused on studying pharmacokinetic aspects of BBB transport of drugs in relation to CNS effects, and it has led to the development of new concepts and methods within the BBB transport area, focusing on unbound drug relationships.


Elizabeth C.M. de Lange (Ph.D.) is Head of the Target Site Equilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR).  Her research program focuses on the development of generally applicable predictive PK/PD models on CNS drugs using advanced in vivo animal models and mathematical modeling techniques, with a number of recent successes.


Robert G. Thorne (Ph.D.) is an Assistant Professor in Pharmaceutical Sciences at the University of Wisconsin-Madison School of Pharmacy. He was previously a research scientist and faculty member in the Department of Physiology & Neuroscience at the New York University School of Medicine. His research focuses on diffusive and convective transport within the CNS and the development, refinement and optimization of strategies for delivering biologics into the brain.


blood-brain barrier drug delivery blood-brain barrier transporters

Editors and affiliations

  • Margareta Hammarlund-Udenaes
    • 1
  • Elizabeth C.M. de Lange
    • 2
  • Robert G. Thorne
    • 3
  1. 1.Pharmaceutical BiosciencesUppsala University Pharmacokinetics and Drug TherapyUppsalaSweden
  2. 2.LACDR/PharmacologyLeiden UniversityLeidenThe Netherlands
  3. 3.Pharmaceutical Sciences DivisionUniversity of Wisconsin-Madison School of PharmacyMadisonUSA

Bibliographic information

  • DOI
  • Copyright Information American Association of Pharmaceutical Scientists 2014
  • Publisher Name Springer, New York, NY
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-1-4614-9104-0
  • Online ISBN 978-1-4614-9105-7
  • Series Print ISSN 2210-7371
  • Series Online ISSN 2210-738X
  • Buy this book on publisher's site
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